| Title |
Purinergic signalling in the liver in health and disease
|
|---|---|
| Published in |
Purinergic Signalling, November 2013
|
| DOI | 10.1007/s11302-013-9398-8 |
| Pubmed ID | |
| Authors |
Geoffrey Burnstock, Byron Vaughn, Simon C. Robson |
| Abstract |
Purinergic signalling is involved in both the physiology and pathophysiology of the liver. Hepatocytes, Kupffer cells, vascular endothelial cells and smooth muscle cells, stellate cells and cholangiocytes all express purinoceptor subtypes activated by adenosine, adenosine 5'-triphosphate, adenosine diphosphate, uridine 5'-triphosphate or UDP. Purinoceptors mediate bile secretion, glycogen and lipid metabolism and indirectly release of insulin. Mechanical stress results in release of ATP from hepatocytes and Kupffer cells and ATP is also released as a cotransmitter with noradrenaline from sympathetic nerves supplying the liver. Ecto-nucleotidases play important roles in the signalling process. Changes in purinergic signalling occur in vascular injury, inflammation, insulin resistance, hepatic fibrosis, cirrhosis, diabetes, hepatitis, liver regeneration following injury or transplantation and cancer. Purinergic therapeutic strategies for the treatment of these pathologies are being explored. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 60 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 16% |
| Researcher | 8 | 13% |
| Student > Doctoral Student | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Student > Postgraduate | 5 | 8% |
| Other | 13 | 21% |
| Unknown | 13 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 21% |
| Biochemistry, Genetics and Molecular Biology | 11 | 18% |
| Agricultural and Biological Sciences | 7 | 11% |
| Immunology and Microbiology | 4 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Other | 9 | 15% |
| Unknown | 15 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2014.
All research outputs
#18,373,874
of 22,757,541 outputs
Outputs from Purinergic Signalling
#237
of 376 outputs
Outputs of similar age
#227,844
of 302,106 outputs
Outputs of similar age from Purinergic Signalling
#5
of 7 outputs
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So far Altmetric has tracked 376 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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