| Title |
The Immune Microenvironment of Myeloma
|
|---|---|
| Published in |
Cancer Microenvironment, August 2011
|
| DOI | 10.1007/s12307-011-0086-3 |
| Pubmed ID | |
| Authors |
Kimberly Noonan, Ivan Borrello |
| Abstract |
The bone marrow (BM) is the site of disease in myeloma and possesses unique immune characteristics involved in the pathobiology of the disease. Interactions of plasma cells with stromal cells, osteoclasts, osteoblasts, myeloid and lymphoid cells make up the unique bone marrow milieu that mediates myeloma disease progression. Independently or through a complex network of interactions these cells impart immune changes leading to immune evasion and disease progression. The critical role of these factors in disease progression has led to the intense development of therapeutic strategies aimed at either disrupting the immune mechanisms mediating disease progression or augmenting those with anti-tumor benefits. This review discusses the major contributors of immunity in the bone marrow microenvironment, their interactions, and mechanisms whereby immune modulation can be translated into therapies with anti-myeloma efficacy. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 83 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 24% |
| Researcher | 20 | 24% |
| Student > Master | 11 | 13% |
| Student > Bachelor | 8 | 9% |
| Other | 4 | 5% |
| Other | 9 | 11% |
| Unknown | 13 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 27% |
| Medicine and Dentistry | 14 | 16% |
| Immunology and Microbiology | 12 | 14% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Chemistry | 3 | 4% |
| Other | 7 | 8% |
| Unknown | 15 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2022.
All research outputs
#4,232,173
of 23,053,169 outputs
Outputs from Cancer Microenvironment
#8
of 92 outputs
Outputs of similar age
#22,586
of 124,730 outputs
Outputs of similar age from Cancer Microenvironment
#1
of 7 outputs
Altmetric has tracked 23,053,169 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them