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Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register

Overview of attention for article published in Biological Psychiatry, September 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 6,613)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

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36 news outlets
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6 blogs
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140 X users
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3 Facebook pages

Citations

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437 Dimensions

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805 Mendeley
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Title
Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register
Published in
Biological Psychiatry, September 2017
DOI 10.1016/j.biopsych.2017.08.017
Pubmed ID
Authors

Rikke Hilker, Dorte Helenius, Birgitte Fagerlund, Axel Skytthe, Kaare Christensen, Thomas M. Werge, Merete Nordentoft, Birte Glenthøj

Abstract

Twin studies have provided evidence that both genetic and environmental factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples have varied methodologically. This study provides updated heritability estimates based on nationwide twin data and an improved statistical methodology. Combining two nationwide registers, the Danish Twin Register and the Danish Psychiatric Research Register, we identified a sample of twins born between 1951 and 2000 (N = 31,524 twin pairs). Twins were followed until June 1, 2011. Liability threshold models adjusting for censoring with inverse probability weighting were used to estimate probandwise concordance rates and heritability of the diagnoses of SZ and SZ spectrum disorders. The probandwise concordance rate of SZ is 33% in monozygotic twins and 7% in dizygotic twins. We estimated the heritability of SZ to be 79%. When expanding illness outcome to include SZ spectrum disorders, the heritability estimate was almost similar (73%). The key strength of this study is the application of a novel statistical method accounting for censoring in the follow-up period to a nationwide twin sample. The estimated 79% heritability of SZ is congruent with previous reports and indicates a substantial genetic risk. The high genetic risk also applies to a broader phenotype of SZ spectrum disorders. The low concordance rate of 33% in monozygotic twins demonstrates that illness vulnerability is not solely indicated by genetic factors.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 805 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 805 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 157 20%
Student > Ph. D. Student 99 12%
Student > Master 97 12%
Researcher 63 8%
Student > Doctoral Student 47 6%
Other 77 10%
Unknown 265 33%
Readers by discipline Count As %
Psychology 114 14%
Neuroscience 110 14%
Medicine and Dentistry 103 13%
Biochemistry, Genetics and Molecular Biology 75 9%
Agricultural and Biological Sciences 43 5%
Other 71 9%
Unknown 289 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 391. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2024.
All research outputs
#78,443
of 25,523,622 outputs
Outputs from Biological Psychiatry
#24
of 6,613 outputs
Outputs of similar age
#1,777
of 324,829 outputs
Outputs of similar age from Biological Psychiatry
#2
of 71 outputs
Altmetric has tracked 25,523,622 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,613 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.