Title |
MOG Spectrum Disorders and Role of MOG-Antibodies in Clinical Practice
|
---|---|
Published in |
Neuropediatrics, August 2017
|
DOI | 10.1055/s-0037-1604404 |
Pubmed ID | |
Authors |
Eva-Maria Hennes, Matthias Baumann, Christian Lechner, Kevin Rostásy |
Abstract |
Myelin oligodendrocyte glycoprotein (MOG) antibodies (abs) are present in one third of all children with an acute demyelinating syndrome (ADS). MOG-abs can be found in acute disseminated encephalomyelitis (ADEM), transverse myelitis, isolated optic neuritis (ON), or recurrent demyelinating diseases, such as multiphasic neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 (AQP4) abs or multiphasic ADEM (MDEM), but rarely in children who subsequently develop multiple sclerosis (MS). The presence of MOG-abs is age dependent with the highest seropositivity rates found in young children and an episode of ADEM, whereas older children with MOG-abs present with ON, myelitis, or brainstem symptoms. MOG-abs, initially thought to be associated with a benign disease course, are found in a substantial proportion of children with relapsing episodes associated with high and persisting MOG-ab titers. This review describes, in particular, the increasing spectrum of phenotypes associated with MOG-abs with a focus on clinical characteristics, radiological features, and therapeutic aspects. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Members of the public | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 94 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 15% |
Other | 12 | 13% |
Student > Master | 9 | 10% |
Student > Postgraduate | 8 | 9% |
Professor > Associate Professor | 7 | 7% |
Other | 19 | 20% |
Unknown | 25 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 46% |
Neuroscience | 13 | 14% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Psychology | 2 | 2% |
Business, Management and Accounting | 1 | 1% |
Other | 4 | 4% |
Unknown | 28 | 30% |