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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The downfall of TBA-354 – a possible explanation for its neurotoxicity via mass spectrometric imaging
|
|---|---|
| Published in |
Xenobiotica, October 2017
|
| DOI | 10.1080/00498254.2017.1375168 |
| Pubmed ID | |
| Authors |
Sphamandla Ntshangase, Adeola Shobo, Hendrik G. Kruger, Arndt Asperger, Dagmar Niemeyer, Per I. Arvidsson, Thavendran Govender, Sooraj Baijnath |
| Abstract |
TBA-354 was a promising antitubercular compound with activity against both replicating and static Mycobacterium tuberculosis (M.tb), making it the focal point of many clinical trials conducted by the TB Alliance. However, findings from these trials have shown that TBA-354 results in mild signs of reversible neurotoxicity; this left the TB Alliance with no other choice but to stop the research. In this study, mass spectrometric methods were used to evaluate the pharmacokinetics and spatial distribution of TBA-354 in the brain using a validated liquid chromatography tandem-mass spectrometry (LC-MS/MS) and mass spectrometric imaging (MSI), respectively. Healthy female Sprague-Dawley rats received intraperitoneal (i.p.) doses of TBA-354 (20 mg/kg.b.w). The concentration-time profiles showed a gradual absorption and tissue penetration of TBA-354 reaching the Cmax at 6 h post dose, followed by a rapid elimination. MSI analysis showed a time-dependent drug distribution, with highest drug concentration mainly in the neocortical regions of the brain. The distribution of TBA-354 provides a possible explanation for the motor dysfunction observed in clinical trials. These results prove the importance of MSI as a potential tool in preclinical evaluations of suspected neurotoxic compounds. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 19% |
| Researcher | 3 | 8% |
| Student > Bachelor | 3 | 8% |
| Professor | 2 | 5% |
| Lecturer > Senior Lecturer | 2 | 5% |
| Other | 9 | 24% |
| Unknown | 11 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 6 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
| Medicine and Dentistry | 3 | 8% |
| Psychology | 3 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Other | 5 | 14% |
| Unknown | 14 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2018.
All research outputs
#14,362,315
of 22,999,744 outputs
Outputs from Xenobiotica
#991
of 1,238 outputs
Outputs of similar age
#180,842
of 325,861 outputs
Outputs of similar age from Xenobiotica
#1
of 5 outputs
Altmetric has tracked 22,999,744 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,238 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,861 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them