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Astrocyte‐like glial cells physiologically regulate olfactory processing through the modification of ORN‐PN synaptic strength in Drosophila

Overview of attention for article published in European Journal of Neuroscience, June 2014
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Title
Astrocyte‐like glial cells physiologically regulate olfactory processing through the modification of ORN‐PN synaptic strength in Drosophila
Published in
European Journal of Neuroscience, June 2014
DOI 10.1111/ejn.12646
Pubmed ID
Authors

He Liu, Bangyu Zhou, Wenjun Yan, Zhengchang Lei, Xiaoliang Zhao, Ke Zhang, Aike Guo

Abstract

Astrocyte-like glial cells are abundant in the central nervous system of adult Drosophila and exhibit morphology similar to astrocytes of mammals. Previous evidence has shown that astrocyte-like glial cells are strongly associated with synapses in the antennal lobe (AL), the first relay of the olfactory system, where olfactory receptor neurons (ORNs) transmit information into projection neurons (PNs). However, the function of astrocyte-like glia in the AL remains obscure. In this study, using in vivo calcium imaging, we found that astrocyte-like glial cells exhibited spontaneous microdomain calcium elevations. Using simultaneous manipulation of glial activity and monitoring of neuronal function, we found that the astrocyte-like glial activation, but not ensheathing glial activation, could inhibit odor-evoked responses of PNs. Ensheathing glial cells are another subtype of glia, and are of functional importance in the AL. Electrophysiological experiments indicated that astrocyte-like glial activation decreased the amplitude and slope of excitatory postsynaptic potentials evoked through electrical stimulation of the antennal nerve. These results suggest that astrocyte-like glial cells may regulate olfactory processing through negative regulation of ORN-PN synaptic strength. Beyond the antennal lobe we observed astrocyte-like glial spontaneous calcium activities in the ventromedial protocerebrum, indicating that astrocyte-like glial spontaneous calcium elevations might be general in the adult fly brain. Overall, our study demonstrates a new function for astrocyte-like glial cells in the physiological modulation of olfactory information transmission, possibly through regulating ORN-PN synapse strength.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Portugal 1 2%
Unknown 63 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 32%
Student > Ph. D. Student 13 20%
Student > Bachelor 8 12%
Student > Postgraduate 4 6%
Student > Master 4 6%
Other 9 14%
Unknown 7 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 41%
Neuroscience 17 26%
Biochemistry, Genetics and Molecular Biology 5 8%
Medicine and Dentistry 4 6%
Engineering 2 3%
Other 3 5%
Unknown 8 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2014.
All research outputs
#19,977,226
of 24,549,201 outputs
Outputs from European Journal of Neuroscience
#5,496
of 6,057 outputs
Outputs of similar age
#169,627
of 232,957 outputs
Outputs of similar age from European Journal of Neuroscience
#58
of 80 outputs
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