Title |
A pilot study to determine the short‐term effects of a low glycemic load diet on hormonal markers of acne: A nonrandomized, parallel, controlled feeding trial
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Published in |
Molecular Nutrition & Food Research, June 2008
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DOI | 10.1002/mnfr.200700307 |
Pubmed ID | |
Authors |
Robyn Smith, Neil Mann, Henna Mäkeläinen, Jessica Roper, Anna Braue, George Varigos |
Abstract |
Observational evidence suggests that dietary glycemic load may be one environmental factor contributing to the variation in acne prevalence worldwide. To investigate the effect of a low glycemic load (LGL) diet on endocrine aspects of acne vulgaris, 12 male acne sufferers (17.0 +/- 0.4 years) completed a parallel, controlled feeding trial involving a 7-day admission to a housing facility. Subjects consumed either an LGL diet (n = 7; 25% energy from protein and 45% from carbohydrates) or a high glycemic load (HGL) diet (n = 5; 15% energy from protein, 55% energy from carbohydrate). Study outcomes included changes in the homeostasis model assessment of insulin resistance (HOMA-IR), sex hormone binding globulin (SHBG), free androgen index (FAI), insulin-like growth factor-I (IGF-I), and its binding proteins (IGFBP-I and IGFBP-3). Changes in HOMA-IR were significantly different between groups at day 7 (-0.57 for LGL vs. 0.14 for HGL, p = 0.03). SHBG levels decreased significantly from baseline in the HGL group (p = 0.03), while IGFBP-I and IGFBP-3 significantly increased (p = 0.03 and 0.03, respectively) in the LGL group. These results suggest that increases in dietary glycemic load may augment the biological activity of sex hormones and IGF-I, suggesting that these diets may aggravate potential factors involved in acne development. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 108 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 28 | 26% |
Other | 11 | 10% |
Researcher | 10 | 9% |
Student > Master | 10 | 9% |
Student > Ph. D. Student | 6 | 6% |
Other | 15 | 14% |
Unknown | 28 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 33% |
Nursing and Health Professions | 11 | 10% |
Agricultural and Biological Sciences | 8 | 7% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Social Sciences | 3 | 3% |
Other | 13 | 12% |
Unknown | 30 | 28% |