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Stromal biology and therapy in pancreatic cancer

Overview of attention for article published in Gut, October 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

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1 X user
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13 patents

Citations

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648 Dimensions

Readers on

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504 Mendeley
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Title
Stromal biology and therapy in pancreatic cancer
Published in
Gut, October 2010
DOI 10.1136/gut.2010.226092
Pubmed ID
Authors

Albrecht Neesse, Patrick Michl, Kristopher K Frese, Christine Feig, Natalie Cook, Mike A Jacobetz, Martijn P Lolkema, Malte Buchholz, Kenneth P Olive, Thomas M Gress, David A Tuveson

Abstract

Pancreatic ductal adenocarcinoma (PDA) is an almost uniformly lethal disease. One explanation for the devastating prognosis is the failure of many chemotherapies, including the current standard of care therapy gemcitabine. Although our knowledge of the molecular events underlying multistep carcinogenesis in PDA has steadily increased, translation into more effective therapeutic approaches has been inefficient over the last several decades. Evidence for this innate resistance to systemic therapies was recently provided in an accurate mouse model of PDA by the demonstration that chemotherapies are poorly delivered to PDA tissues because of a deficient vasculature. This vascular deficiency correlated with the presence of a dense stromal matrix that is a prominent histological hallmark of PDA tumours. Therapeutic targeting of stromal cells decreased the stroma from pancreatic tumours, resulting in increased intratumoral perfusion and therapeutic delivery of gemcitabine. Stromal cells contained within the PDA tumour microenvironment therefore represent an additional constituent to neoplastic cells that should be critically evaluated for optimal therapeutic development in preclinical models and early clinical trials.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 504 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 1%
Germany 4 <1%
France 3 <1%
Australia 1 <1%
Canada 1 <1%
United Kingdom 1 <1%
Unknown 488 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 123 24%
Researcher 81 16%
Student > Master 55 11%
Student > Bachelor 54 11%
Student > Doctoral Student 27 5%
Other 77 15%
Unknown 87 17%
Readers by discipline Count As %
Medicine and Dentistry 119 24%
Biochemistry, Genetics and Molecular Biology 107 21%
Agricultural and Biological Sciences 95 19%
Pharmacology, Toxicology and Pharmaceutical Science 21 4%
Immunology and Microbiology 16 3%
Other 40 8%
Unknown 106 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#3,415,510
of 25,374,917 outputs
Outputs from Gut
#1,810
of 7,373 outputs
Outputs of similar age
#13,560
of 108,572 outputs
Outputs of similar age from Gut
#8
of 57 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,373 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,572 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.