| Title |
The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review
|
|---|---|
| Published in |
Clinical Reviews in Allergy & Immunology, June 2014
|
| DOI | 10.1007/s12016-014-8431-1 |
| Pubmed ID | |
| Authors |
Divi Cornec, Alain Saraux, Sandrine Jousse-Joulin, Jacques-Olivier Pers, Sylvie Boisramé-Gastrin, Yves Renaudineau, Yves Gauvin, Anne-Marie Roguedas-Contios, Steeve Genestet, Myriam Chastaing, Béatrice Cochener, Valérie Devauchelle-Pensec |
| Abstract |
Primary Sjögren's syndrome (pSS) is a frequent autoimmune systemic disease, clinically characterized by eyes and mouth dryness in all patients, salivary gland swelling or extraglandular systemic manifestations in half of the patients, and development of lymphoma in 5 to 10 % of the patients. However, patients presenting with sicca symptoms or salivary gland swelling may have a variety of conditions that may require very different investigations, treatments, or follow-up. Eye and/or mouth dryness is a frequent complaint in clinical setting, and its frequency increases with age. When evaluating a patient with suspected pSS, the first step is to rule out its differential diagnoses, before looking for positive arguments for the disease. Knowledge of normal and abnormal lachrymal and salivary gland physiology allows the clinician to prescribe the most adapted procedures for evaluating their function and structure. New tests have been developed in recent years for evaluating these patients, notably new ocular surface staining scores or salivary gland ultrasonography. We describe the different diagnoses performed in our monocentric cohort of 240 patients with suspected pSS. The most frequent diagnoses are pSS, other systemic autoimmune diseases, idiopathic sicca syndrome and drug-induced sicca syndrome. However, other diseases are important to rule out due to their specific management, such as sarcoidosis, granulomatosis with polyangeitis, IgG4-related disease, chronic hepatitis C virus or human immunodeficiency virus infections, graft-versus-host disease, and head and neck radiation therapy. At the light of these data, we propose a core of minimal investigations to be performed when evaluating a patient with suspected pSS. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Colombia | 1 | 1% |
| Netherlands | 1 | 1% |
| Australia | 1 | 1% |
| Spain | 1 | 1% |
| Japan | 1 | 1% |
| Unknown | 86 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 15% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 11 | 12% |
| Other | 10 | 11% |
| Student > Postgraduate | 8 | 9% |
| Other | 22 | 24% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 57% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Agricultural and Biological Sciences | 3 | 3% |
| Immunology and Microbiology | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 22 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2024.
All research outputs
#14,868,824
of 25,793,330 outputs
Outputs from Clinical Reviews in Allergy & Immunology
#477
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Outputs of similar age
#119,315
of 243,679 outputs
Outputs of similar age from Clinical Reviews in Allergy & Immunology
#8
of 14 outputs
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