| Title |
Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, August 2011
|
| DOI | 10.1007/s11010-011-1030-z |
| Pubmed ID | |
| Authors |
Guanghui Chu, Shengbin Qi, Guodong Yang, Kefeng Dou, Jianjun Du, Zifan Lu |
| Abstract |
The novel gene GDDR, also named trefoil factor interactions 1, is abundantly expressed in human gastric epithelial cells but significantly down-regulated in gastric cancer. In this study, we first demonstrated that GDDR was specifically expressed in the gastrointestinal tract epithelium, while suppressed in gastric cancer cells. Forced expression of GDDR suppressed the tumor growth as shown by MTT and xenograft assay. siRNA mediated TFF1 inhibition nearly blocked the growth inhibitory role of GDDR. In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 67% |
| Unknown | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 33% |
| Medicine and Dentistry | 1 | 33% |
| Unknown | 1 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2011.
All research outputs
#18,295,723
of 22,651,245 outputs
Outputs from Molecular and Cellular Biochemistry
#1,552
of 2,287 outputs
Outputs of similar age
#102,204
of 124,037 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#20
of 28 outputs
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