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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neuronal activity modifies the DNA methylation landscape in the adult brain
|
|---|---|
| Published in |
Nature Neuroscience, August 2011
|
| DOI | 10.1038/nn.2900 |
| Pubmed ID | |
| Authors |
Junjie U Guo, Dengke K Ma, Huan Mo, Madeleine P Ball, Mi-Hyeon Jang, Michael A Bonaguidi, Jacob A Balazer, Hugh L Eaves, Bin Xie, Eric Ford, Kun Zhang, Guo-li Ming, Yuan Gao, Hongjun Song |
| Abstract |
DNA methylation has been traditionally viewed as a highly stable epigenetic mark in postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation changes, at least in a few identified CpG dinucleotides. How extensively the neuronal DNA methylome is regulated by neuronal activity is unknown. Using a next-generation sequencing-based method for genome-wide analysis at single-nucleotide resolution, we quantitatively compared the CpG methylation landscape of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation. About 1.4% of 219,991 CpGs measured showed rapid active demethylation or de novo methylation. Some modifications remained stable for at least 24 h. These activity-modified CpGs showed a broad genomic distribution with significant enrichment in low-CpG density regions, and were associated with brain-specific genes related to neuronal plasticity. Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 25% |
| Canada | 2 | 17% |
| United States | 1 | 8% |
| Unknown | 6 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 75% |
| Scientists | 3 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 681 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 2% |
| Japan | 4 | <1% |
| Germany | 3 | <1% |
| United Kingdom | 3 | <1% |
| Canada | 3 | <1% |
| Portugal | 2 | <1% |
| India | 2 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Other | 6 | <1% |
| Unknown | 639 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 191 | 28% |
| Researcher | 128 | 19% |
| Student > Master | 71 | 10% |
| Student > Bachelor | 50 | 7% |
| Professor | 42 | 6% |
| Other | 133 | 20% |
| Unknown | 66 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 291 | 43% |
| Neuroscience | 108 | 16% |
| Biochemistry, Genetics and Molecular Biology | 77 | 11% |
| Medicine and Dentistry | 58 | 9% |
| Psychology | 26 | 4% |
| Other | 49 | 7% |
| Unknown | 72 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2023.
All research outputs
#1,544,388
of 25,563,770 outputs
Outputs from Nature Neuroscience
#2,086
of 5,640 outputs
Outputs of similar age
#6,845
of 135,032 outputs
Outputs of similar age from Nature Neuroscience
#13
of 63 outputs
Altmetric has tracked 25,563,770 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,640 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.6. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 135,032 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.