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A double‐blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome

Overview of attention for article published in American Journal of Medical Genetics. Part A, June 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

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3 X users
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6 patents
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1 Facebook page

Citations

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110 Dimensions

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108 Mendeley
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Title
A double‐blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome
Published in
American Journal of Medical Genetics. Part A, June 2014
DOI 10.1002/ajmg.a.36653
Pubmed ID
Authors

Stewart L. Einfeld, Ellie Smith, Iain S. McGregor, Kate Steinbeck, John Taffe, Lauren J. Rice, Siân K. Horstead, Naomi Rogers, M. Antoinette Hodge, Adam J. Guastella

Abstract

Individuals with Prader-Willi syndrome (PWS) have a significant reduction in the number of oxytocin-producing neurons (42%) in the hypothalamic paraventricular nucleus. A number of animal studies and observations of humans show that lesions in this region can produce PWS-like symptoms. Given the evidence for potential oxytocin deficiency, we tested the effects of a course of intranasal oxytocin on PWS symptoms. Thirty individuals with PWS aged 12-30 years participated in an 18-week randomized double-blind placebo-controlled crossover trial. Participants received 8 weeks of oxytocin and 8 weeks of placebo with a minimum 2-week washout period. The first 11 participants received the following oxytocin doses: 24 IU (twice daily) B.I.D for participants 16 years and over and 18 IU B.I.D for participants 13-15 years. The dose was increased for the remaining 18 participants to 40 IU B.I.D for participants 16 years and over and 32 IU B.I.D for 13-15 years. Measures used to assess changes were standardized well-accepted measures, including the Developmental Behavior Checklist-Monitor, Parent, Teacher, and Adult; The Yale-Brown Obsessive Compulsive Scale; The Dykens Hyperphagia questionnaire; Reading The Mind in the Eyes Test; Epworth Sleepiness Scale and the Movie Stills. Oxytocin had little impact on any measure. The only significant difference found between the baseline, oxytocin, and placebo measures was an increase in temper outbursts (P = 0.023) with higher dose oxytocin. The lack of effect of oxytocin nasal spray may reflect the importance of endogenous release of oxytocin in response to exogenous oxytocin.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
Unknown 106 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 20%
Researcher 12 11%
Student > Master 9 8%
Student > Bachelor 8 7%
Other 7 6%
Other 20 19%
Unknown 30 28%
Readers by discipline Count As %
Psychology 23 21%
Medicine and Dentistry 22 20%
Agricultural and Biological Sciences 10 9%
Neuroscience 6 6%
Nursing and Health Professions 3 3%
Other 12 11%
Unknown 32 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#3,083,569
of 25,394,764 outputs
Outputs from American Journal of Medical Genetics. Part A
#202
of 4,210 outputs
Outputs of similar age
#29,817
of 241,999 outputs
Outputs of similar age from American Journal of Medical Genetics. Part A
#3
of 67 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,210 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,999 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.