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The effect of space flight on human cellular immunity.

Overview of attention for article published in Annual Report of the Research Institute of Environmental Medicine, Nagoya University, January 1993
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Title
The effect of space flight on human cellular immunity.
Published in
Annual Report of the Research Institute of Environmental Medicine, Nagoya University, January 1993
Pubmed ID
Authors

A Cogoli

Abstract

T-lymphocyte responsiveness to mitogens is depressed by an average of 56% in humans (129 subjects) tested during and after space flight. Although there is not yet conclusive evidence of a clinical significance of the test, it is clear that factors of space flight like stress, closed environment and cosmic radiation may affect immune responsiveness. The data obtained from space crews may be compared to the depression seen in subjects undergoing heavy physical stress of head down tilt bedrest. Recently, delayed hypersensitivity [correction of hypersensivity] response was tested on crews of the US space shuttle and of the orbital station MIR by means of a commercially available "skin test". Again, the response was lower in 14 of the 15 subjects tested. In two cases, a strong in flight depression could be related to heavy physical and psychological stress experienced in flight. The data available today are not sufficient to draw conclusions on the hazard of infectious diseases during and after space flight. Although the changes observed never harmed the health of astronauts, immunological changes must be seriously investigated and understood in view of long-duration flights on space stations in an Earth orbit and to other planets like Mars and the Moon.

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Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 22%
Student > Doctoral Student 3 13%
Student > Bachelor 3 13%
Student > Postgraduate 2 9%
Professor 1 4%
Other 2 9%
Unknown 7 30%
Readers by discipline Count As %
Medicine and Dentistry 6 26%
Biochemistry, Genetics and Molecular Biology 3 13%
Sports and Recreations 2 9%
Earth and Planetary Sciences 1 4%
Agricultural and Biological Sciences 1 4%
Other 2 9%
Unknown 8 35%