Title |
Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial
|
---|---|
Published in |
Endocrine, June 2014
|
DOI | 10.1007/s12020-014-0336-5 |
Pubmed ID | |
Authors |
Nasrin Sharifi, Reza Amani, Eskandar Hajiani, Bahman Cheraghian |
Abstract |
The aim of this study was to investigate the effects of vitamin D supplementation on serum aminotransferases, insulin resistance, oxidative stress, and inflammatory biomarkers in adult patients with non-alcoholic fatty liver disease (NAFLD). Fifty-three patients with NAFLD were enrolled in a parallel, double-blind, placebo-controlled study. The patients were randomly allocated to receive either one oral pearl consisting of 50,000 IU vitamin D3 (n = 27) or a placebo (n = 26), every 14 days for 4 months. Serum aminotransferases, high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor α, malondialdehyde (MDA), total antioxidant capacity, transforming growth factor β1, as well as grade of hepatic steatosis and homeostasis model assessment of insulin resistance were assessed pre- and post-intervention. In patients who received vitamin D supplement compared to the controls, the median of serum 25(OH)D3 significantly increased (16.2 vs. 1.6 ng/ml, P < 0.001). This increase accompanied by significant decrease in serum MDA (-2.09 vs. -1.23 ng/ml, P = 0.03) and near significant changes in serum hs-CRP (-0.25 vs. 0.22 mg/l, P = 0.06). These between-group differences remained significant even after controlling for baseline covariates. Other variables showed no significant changes. Improved vitamin D status led to amelioration in serum hs-CRP and MDA in patients with NAFLD. This might be considered as an adjunctive therapy to attenuate systemic inflammation and lipid peroxidation alongside other treatments for NAFLD patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | <1% |
New Zealand | 1 | <1% |
Unknown | 150 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 13% |
Student > Bachelor | 18 | 12% |
Student > Ph. D. Student | 15 | 10% |
Researcher | 10 | 7% |
Student > Postgraduate | 10 | 7% |
Other | 31 | 20% |
Unknown | 48 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 45 | 30% |
Biochemistry, Genetics and Molecular Biology | 18 | 12% |
Agricultural and Biological Sciences | 14 | 9% |
Nursing and Health Professions | 9 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 9 | 6% |
Unknown | 54 | 36% |