| Title |
Hancornia speciosa latex for biomedical applications: physical and chemical properties, biocompatibility assessment and angiogenic activity
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, June 2014
|
| DOI | 10.1007/s10856-014-5255-8 |
| Pubmed ID | |
| Authors |
Luciane Madureira Almeida, Juliana Ferreira Floriano, Thuanne Pires Ribeiro, Lais Nogueira Magno, Lígia Souza Lima Silveira da Mota, Nei Peixoto, Fátima Mrué, Paulo Melo-Reis, Ruy de Souza Lino Junior, Carlos Frederico de Oliveira Graeff, Pablo José Gonçalves |
| Abstract |
The latex obtained from Hancornia speciosa is used in folk medicine for treatment of several diseases, such as acne, warts, diabetes, gastritis and inflammation. In this work, we describe the biocompatibility assessment and angiogenic properties of H. speciosa latex and its potential application in medicine. The physical-chemical characterization was carried out following different methodologies (CHN elemental analyses; thermogravimetric analyses and Fourier transform infrared spectroscopy). The biocompatibility was evaluated through cytotoxicity and genotoxicity tests in fibroblast mouse cells and the angiogenic properties were evaluated using the chick chorioallantoic membrane (CAM) assay model. The physical-chemical results showed that the structure of Hancornia speciosa latex biomembrane is very similar to that of Hevea brasiliensis (commercially available product). Moreover, the cytotoxicity and genotoxicity assays showed that H. speciosa latex is biocompatible with life systems and can be a good biomaterial for medical applications. The CAM test showed the efficient ability of H. speciosa latex in neovascularization of tissues. The histological analysis was in accordance with the results obtained in the CAM assay. Our data indicate that the latex obtained from H. speciosa and eluted in water showed significant angiogenic activity without any cytotoxic or genotoxic effects on life systems. The same did not occur with H. speciosa latex stabilized with ammonia. Addition of ammonia does not have significant effects on the structure of biomembranes, but showed a smaller cell survival and a significant genotoxicity effect. This study contributes to the understanding of the potentialities of H. speciosa latex as a source of new phytomedicines. |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| Unknown | 79 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 16% |
| Professor | 9 | 11% |
| Student > Postgraduate | 9 | 11% |
| Student > Bachelor | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Other | 17 | 21% |
| Unknown | 18 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 21% |
| Biochemistry, Genetics and Molecular Biology | 12 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Medicine and Dentistry | 6 | 7% |
| Physics and Astronomy | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 23 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2014.
All research outputs
#20,232,430
of 22,758,248 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#1,288
of 1,400 outputs
Outputs of similar age
#191,652
of 227,015 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#14
of 16 outputs
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So far Altmetric has tracked 1,400 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.