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Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression

Overview of attention for article published in Antiviral Research, April 2014
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  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

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Title
Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression
Published in
Antiviral Research, April 2014
DOI 10.1016/j.antiviral.2014.04.005
Pubmed ID
Authors

Nadejda Beliakova-Bethell, Sonia Jain, Christopher H. Woelk, Mallory D. Witt, Xiaoying Sun, Steven M. Lada, Celsa A. Spina, Miguel Goicoechea, Steffney E. Rought, Richard Haubrich, Michael P. Dubé

Abstract

Addition of the CCR5 inhibitor Maraviroc (MVC) to ongoing antiretroviral therapy increases CD4+ T cell counts in some virologically suppressed patients with suboptimal CD4+ T cell recovery. To understand the mechanisms by which MVC elicits increases in CD4+ T cell counts, the present study was undertaken to identify host factors (i.e. genes) that are modulated and are correlated with CD4+ T cell recovery during the 24weeks of MVC intensification in 32 subjects. Median changes of CD4+ T cell counts over 24weeks of MVC compared to baseline were 38cells/mm(3) (p<0.001). The median slope of CD4+ T cell recovery was 39cells/mm(3) per year before initiation of MVC and 76cells/mm(3) per year during MVC intensification, however, this increase was not statistically significant (p=0.33). Microarray analysis (N=31,426 genes) identified a single differentially expressed gene, tumor necrosis factor alpha (TNF), which was modestly (1.44-fold, p<0.001) downregulated by MVC at week 24 compared to baseline. TNF differential expression was evaluated using an independent method of droplet digital PCR, but the difference was not significant (p=0.6). Changes in gene expression did not correlate with CD4+ T cell recovery or any changes in the CD4+ T cell maturation, proliferation and activation phenotypes. In summary, our data suggest that modest improvements of CD4+ T cell counts during MVC intensification cannot be explained by changes in gene expression elicited by MVC. However, the modest changes in T cell composition, including reduction of the percentages of Tregs, proliferating CD4+ T cells and senescent CD8+ T cells, suggest immunologically favorable effects of MVC.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Other 9 30%
Researcher 6 20%
Student > Ph. D. Student 4 13%
Student > Master 3 10%
Student > Postgraduate 2 7%
Other 1 3%
Unknown 5 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 33%
Medicine and Dentistry 7 23%
Biochemistry, Genetics and Molecular Biology 3 10%
Immunology and Microbiology 2 7%
Environmental Science 1 3%
Other 2 7%
Unknown 5 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2016.
All research outputs
#8,262,445
of 25,374,917 outputs
Outputs from Antiviral Research
#1,201
of 2,834 outputs
Outputs of similar age
#76,647
of 241,718 outputs
Outputs of similar age from Antiviral Research
#16
of 36 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 2,834 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.5. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,718 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.