| Title |
Repeated administration of berberine inhibits cytochromes P450 in humans
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, August 2011
|
| DOI | 10.1007/s00228-011-1108-2 |
| Pubmed ID | |
| Authors |
Ying Guo, Yao Chen, Zhi-rong Tan, Curtis D. Klaassen, Hong-hao Zhou |
| Abstract |
Berberine is a plant alkaloid that is widely used to treat gastrointestinal infections, diabetes, hypertension, and hypercholesterolemia. Many studies have reported interactions between berberine-containing products and cytochromes P450 (CYPs), but little is known about whether berberine alters CYP activities in humans, especially after repeated doses. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| New Zealand | 1 | 7% |
| Unknown | 9 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 79% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
| Scientists | 1 | 7% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 131 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 13% |
| Student > Bachelor | 16 | 12% |
| Researcher | 15 | 11% |
| Student > Master | 15 | 11% |
| Other | 10 | 7% |
| Other | 27 | 20% |
| Unknown | 34 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 17% |
| Agricultural and Biological Sciences | 10 | 7% |
| Nursing and Health Professions | 7 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Other | 18 | 13% |
| Unknown | 42 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2024.
All research outputs
#3,660,783
of 25,761,363 outputs
Outputs from European Journal of Clinical Pharmacology
#310
of 2,776 outputs
Outputs of similar age
#18,489
of 135,663 outputs
Outputs of similar age from European Journal of Clinical Pharmacology
#1
of 12 outputs
Altmetric has tracked 25,761,363 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,776 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 135,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.