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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Characterization of monkeypox virus infection in African rope squirrels (Funisciurus sp.)
|
|---|---|
| Published in |
PLoS Neglected Tropical Diseases, August 2017
|
| DOI | 10.1371/journal.pntd.0005809 |
| Pubmed ID | |
| Authors |
Elizabeth A. Falendysz, Juan G. Lopera, Jeffrey B. Doty, Yoshinori Nakazawa, Colleen Crill, Faye Lorenzsonn, Lem’s N. Kalemba, Monica D. Ronderos, Andres Mejia, Jean M. Malekani, Kevin Karem, Darin S. Carroll, Jorge E. Osorio, Tonie E. Rocke |
| Abstract |
Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, as serosurveillance data in Central Africa has confirmed the circulation of the virus in these rodent species [1,2]. In order to understand the tissue tropism and clinical signs associated with infection with MPXV in these species, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to express the luciferase gene. After infection, we monitored viral replication and shedding via in vivo bioluminescent imaging, viral culture and real time PCR. MPXV infection in African rope squirrels caused mortality and moderate to severe morbidity, with clinical signs including pox lesions in the skin, eyes, mouth and nose, dyspnea, and profuse nasal discharge. Both intranasal and intradermal exposures induced high levels of viremia, fast systemic spread, and long periods of viral shedding. Shedding and luminescence peaked at day 6 post infection and was still detectable after 15 days. Interestingly, one sentinel animal, housed in the same room but in a separate cage, also developed severe MPX disease and was euthanized. This study indicates that MPXV causes significant pathology in African rope squirrels and infected rope squirrels shed large quantities of virus, supporting their role as a potential source of MPXV transmission to humans and other animals in endemic MPX regions. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 10% |
| Spain | 3 | 6% |
| United Kingdom | 3 | 6% |
| Canada | 2 | 4% |
| Netherlands | 1 | 2% |
| Germany | 1 | 2% |
| Australia | 1 | 2% |
| Ireland | 1 | 2% |
| Unknown | 32 | 65% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 82% |
| Practitioners (doctors, other healthcare professionals) | 3 | 6% |
| Science communicators (journalists, bloggers, editors) | 3 | 6% |
| Scientists | 2 | 4% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 11% |
| Student > Master | 8 | 9% |
| Student > Postgraduate | 6 | 7% |
| Other | 5 | 5% |
| Student > Ph. D. Student | 5 | 5% |
| Other | 19 | 21% |
| Unknown | 38 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 15% |
| Agricultural and Biological Sciences | 12 | 13% |
| Veterinary Science and Veterinary Medicine | 5 | 5% |
| Nursing and Health Professions | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 10 | 11% |
| Unknown | 43 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2023.
All research outputs
#1,176,798
of 25,706,302 outputs
Outputs from PLoS Neglected Tropical Diseases
#683
of 9,457 outputs
Outputs of similar age
#23,340
of 326,559 outputs
Outputs of similar age from PLoS Neglected Tropical Diseases
#33
of 237 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,457 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,559 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 237 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.