| Title |
Local Injections of Adipose-Derived Mesenchymal Stem Cells Modulate Inflammation and Increase Angiogenesis Ameliorating the Dystrophic Phenotype in Dystrophin-Deficient Skeletal Muscle
|
|---|---|
| Published in |
Stem Cell Reviews and Reports, August 2011
|
| DOI | 10.1007/s12015-011-9304-0 |
| Pubmed ID | |
| Authors |
Carlos Hermano da Justa Pinheiro, Jean César Farias de Queiroz, Lucas Guimarães-Ferreira, Kaio Fernando Vitzel, Renato Tadeu Nachbar, Luís Gustavo Oliveira de Sousa, Alcione Lescano de Souza-Jr, Maria Tereza Nunes, Rui Curi |
| Abstract |
The effects of adipose-derived mesenchymal stem cells (ADMSC) transplantation on degeneration, regeneration and skeletal muscle function were investigated in dystrophin-deficient mice (24-week-old). ADMSC transplantation improved muscle strength and, resistance to fatigue. An increase in fiber cross-sectional area and in the number of fibers with centralized nuclei and augment of myogenin content were observed. In ADMSC-treated muscles a decrease in muscle content of TNF-α, IL-6 and oxidative stress measured by Amplex(®) reagent were observed. The level of TGF-β1 was lowered whereas that of VEGF, IL-10 and IL-4 were increased by ADMSC treatment. An increase in markers of macrophage M1 (CD11 and F4-80) and a decrease in T lymphocyte marker (CD3) and arginase-1 were also observed in ADMSCs-treated dystrophic muscle. No change was observed in iNOS expression. Increased phosphorylation of Akt, p70S6k and 4E-BP1 was found in dystrophic muscles treated with ADMSC. These results suggest that ADMSC transplantation modulates inflammation and improves muscle tissue regeneration, ameliorating the dystrophic phenotype in dystrophin-deficient mice. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 4% |
| Canada | 1 | 1% |
| Denmark | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 64 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 21% |
| Student > Master | 12 | 17% |
| Student > Ph. D. Student | 11 | 15% |
| Student > Bachelor | 8 | 11% |
| Other | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 28% |
| Medicine and Dentistry | 12 | 17% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Engineering | 6 | 8% |
| Psychology | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 15 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2011.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Stem Cell Reviews and Reports
#914
of 1,036 outputs
Outputs of similar age
#123,800
of 134,431 outputs
Outputs of similar age from Stem Cell Reviews and Reports
#12
of 13 outputs
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