Title |
Effects of chronic leptin infusion on subsequent body weight and composition in mice: Can body weight set point be reset?a
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Published in |
Molecular Metabolism, March 2014
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DOI | 10.1016/j.molmet.2014.02.003 |
Pubmed ID | |
Authors |
Y. Ravussin, C.A. LeDuc, K. Watanabe, B.R. Mueller, A. Skowronski, M. Rosenbaum, R.L. Leibel |
Abstract |
Circulating leptin concentrations correlate with fat mass and signal the status of somatic energy stores to the brain. Previous studies suggest that diet-induced elevations of body weight increase body weight "set-point". To assess whether chronic hyperleptinemia is responsible for this shift in defended body weight, we elevated circulating leptin concentrations in lean mice to those comparable to diet-induced obese mice for eighteen weeks. We hypothesized that following cessation of leptin infusion, a higher body weight would be defended. Compared to saline-infused controls, leptin-infused mice had elevated circulating leptin concentrations, gained less weight, yet had similar metabolic rates. Following cessation of leptin administration, leptin-infused mice gained some weight yet plateaued at 5-10% below controls. These results suggest that, unlike mice rendered hyperleptinemic by diet-induced weight gain, leptin-infused mice do not subsequently "defend" a higher body weight, suggesting that hyperleptinemia per se does not mimic the CNS consequences of chronic weight gain. |
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