| Title |
Telomere Shortening and Alzheimer’s Disease
|
|---|---|
| Published in |
NeuroMolecular Medicine, November 2012
|
| DOI | 10.1007/s12017-012-8207-9 |
| Pubmed ID | |
| Authors |
Zhiyou Cai, Liang-Jun Yan, Anna Ratka |
| Abstract |
Telomeres, at the ends of chromosomes and strands of genetic material, become shorter as cells divide in the process of aging. Telomere length has been considered as a biological marker of age. Telomere length shortening has also been evidenced as the causable role in age-related neurodegenerative diseases, including Alzheimer's disease (AD). It has been demonstrated that telomere shortening has been associated with cognitive impairment, amyloid pathology and hyper-phosphorylation of tau in AD and plays an important role in the pathogenesis of AD via the mechanism of oxidative stress and inflammation. However, it seems that there is no relationship between telomere shortening and AD. Therefore, it is essential for further clarification of telomere-related pathogenesis in AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 1 | <1% |
| Unknown | 151 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 19% |
| Researcher | 21 | 14% |
| Student > Ph. D. Student | 20 | 13% |
| Student > Master | 17 | 11% |
| Other | 10 | 6% |
| Other | 26 | 17% |
| Unknown | 32 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 17% |
| Medicine and Dentistry | 21 | 14% |
| Agricultural and Biological Sciences | 19 | 12% |
| Neuroscience | 19 | 12% |
| Psychology | 8 | 5% |
| Other | 22 | 14% |
| Unknown | 40 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2023.
All research outputs
#1,328,816
of 23,477,147 outputs
Outputs from NeuroMolecular Medicine
#11
of 457 outputs
Outputs of similar age
#7,518
of 160,737 outputs
Outputs of similar age from NeuroMolecular Medicine
#1
of 2 outputs
Altmetric has tracked 23,477,147 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 457 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,737 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them