| Title |
Antipsychotic-induced parkinsonism is associated with working memory deficits in schizophrenia-spectrum disorders
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, June 2014
|
| DOI | 10.1007/s00406-014-0511-y |
| Pubmed ID | |
| Authors |
Stéphane Potvin, Ginette Aubin, Emmanuel Stip |
| Abstract |
In view of the significant cognitive deficits in schizophrenia and their impact on patients' social and occupational functioning, and considering that the influence potential influence of antipsychotic-induced extrapyramidal symptoms on cognition in schizophrenia remains poorly understood, the current study sought to identify the clinical, socio-demographic and neurologic predictors of the cognitive performance of schizophrenia patients. Eighty-two schizophrenia-spectrum (DSM-IV criteria) outpatients were recruited. Psychiatric symptoms were evaluated with the Positive And Negative Syndrome Scale and the Calgary Depression Scale for Schizophrenia. Extrapyramidal symptoms were evaluated with the Extrapyramidal Symptoms Rating Scale, while spatial working, planning abilities and visual paired associates learning were evaluated with the CAmbridge Neuropsychological Tests Automated Battery. The Stroop test was also administered. Multivariate hierarchic linear regression analyses were performed. We found that negative symptoms were associated with cognitive flexibility, planning, visual learning and working memory performance in schizophrenia. Age, sex, number of hospitalizations and antipsychotic type also emerged as significant predictors. More importantly, we found a significant association between antipsychotic-induced parkinsonism and working memory performance. The fact that negative symptoms and socio-demographic variables predicted cognitive performance in schizophrenia is consistent with the previous literature on the topic. The finding of an association between parkinsonism and working memory may have clinical implications, since working memory deficits are considered putative endophenotypes of schizophrenia and are known to impair patients' social and occupational functioning. Our results will need to be replicated in longitudinal studies involving larger samples of patients. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 91 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 19% |
| Student > Ph. D. Student | 14 | 15% |
| Researcher | 12 | 13% |
| Student > Bachelor | 10 | 11% |
| Other | 5 | 5% |
| Other | 13 | 14% |
| Unknown | 21 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 29 | 31% |
| Medicine and Dentistry | 12 | 13% |
| Neuroscience | 6 | 6% |
| Sports and Recreations | 5 | 5% |
| Business, Management and Accounting | 4 | 4% |
| Other | 8 | 9% |
| Unknown | 29 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2015.
All research outputs
#19,221,261
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#987
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Outputs of similar age
#166,420
of 230,266 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#4
of 8 outputs
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