| Title |
Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters
|
|---|---|
| Published in |
Microchimica Acta, July 2014
|
| DOI | 10.1007/s00604-014-1308-4 |
| Pubmed ID | |
| Authors |
Bankim J. Sanghavi, Otto S. Wolfbeis, Thomas Hirsch, Nathan S. Swami |
| Abstract |
Nanomaterial-modified detection systems represent a chief driver towards the adoption of electrochemical methods, since nanomaterials enable functional tunability, ability to self-assemble, and novel electrical, optical and catalytic properties that emerge at this scale. This results in tremendous gains in terms of sensitivity, selectivity and versatility. We review the electrochemical methods and mechanisms that may be applied to the detection of neurological drugs. We focus on understanding how specific nano-sized modifiers may be applied to influence the electron transfer event to result in gains in sensitivity, selectivity and versatility of the detection system. This critical review is structured on the basis of the Anatomical Therapeutic Chemical (ATC) Classification System, specifically ATC Code N (neurotransmitters). Specific sections are dedicated to the widely used electrodes based on the carbon materials, supporting electrolytes, and on electrochemical detection paradigms for neurological drugs and neurotransmitters within the groups referred to as ATC codes N01 to N07. We finally discuss emerging trends and future challenges such as the development of strategies for simultaneous detection of multiple targets with high spatial and temporal resolutions, the integration of microfluidic strategies for selective and localized analyte pre-concentration, the real-time monitoring of neurotransmitter secretions from active cell cultures under electro- and chemotactic cues, aptamer-based biosensors, and the miniaturization of the sensing system for detection in small sample volumes and for enabling cost savings due to manufacturing scale-up. The Electronic Supporting Material (ESM) includes review articles dealing with the review topic in last 40 years, as well as key properties of the analytes, viz., pKa values, half-life of drugs and their electrochemical mechanisms. The ESM also defines analytical figures of merit of the drugs and neurotransmitters. The article contains 198 references in the main manuscript and 207 references in the Electronic Supporting Material. Figureᅟ |
Mendeley readers
The data shown below were compiled from readership statistics for 302 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Czechia | 1 | <1% |
| China | 1 | <1% |
| Oman | 1 | <1% |
| Greece | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 295 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 73 | 24% |
| Student > Master | 41 | 14% |
| Researcher | 32 | 11% |
| Student > Doctoral Student | 19 | 6% |
| Student > Bachelor | 17 | 6% |
| Other | 48 | 16% |
| Unknown | 72 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 110 | 36% |
| Engineering | 33 | 11% |
| Biochemistry, Genetics and Molecular Biology | 13 | 4% |
| Materials Science | 12 | 4% |
| Agricultural and Biological Sciences | 11 | 4% |
| Other | 36 | 12% |
| Unknown | 87 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2018.
All research outputs
#6,406,063
of 22,758,248 outputs
Outputs from Microchimica Acta
#154
of 1,386 outputs
Outputs of similar age
#60,419
of 225,828 outputs
Outputs of similar age from Microchimica Acta
#1
of 15 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,386 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.