| Title |
MiR-26a inhibits prostate cancer progression by repression of Wnt5a
|
|---|---|
| Published in |
Tumor Biology, June 2014
|
| DOI | 10.1007/s13277-014-2206-4 |
| Pubmed ID | |
| Authors |
Shijia Zhao, Xiangdong Ye, Lei Xiao, Xuexiong Lian, Yupeng Feng, Feng Li, Li Li |
| Abstract |
MicroRNAs (miRNAs) are small noncoding RNAs that are involved in different biological processes by suppressing target gene expression. miRNA microarray analysis revealed a significant decrease of miR-26a in prostate cancer tissues versus their normal counterparts, but the role of miR-26a is needed to investigate. In the present study, we found that miR-26a expression was lower in prostate cancer tissues compared with their normal controls, so did the prostate cancer cells. Next, by lentivirus-mediated gain-of-function studies, it was showed that stable miR-26a inhibited cell proliferation, metastasis, and epithelial mesenchymal transition and induced G1 phase arrest in prostate cancer. It was predicted that Wnt5a was a potential target gene of miR-26a by bioinformatics analysis. Then, luciferase assay and Western blot analysis identified that Wnt5a was a new direct target gene of miR-26a and miR-26a inhibited prostate cancer progression via Wnt5a. Altogether, the findings suggested that miR-26a may function as a tumor suppressor in prostate cancer by targeting Wnt5a. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Canada | 1 | 4% |
| Unknown | 24 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 35% |
| Student > Doctoral Student | 5 | 19% |
| Student > Ph. D. Student | 4 | 15% |
| Student > Bachelor | 2 | 8% |
| Professor | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 27% |
| Medicine and Dentistry | 7 | 27% |
| Agricultural and Biological Sciences | 7 | 27% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Unknown | 4 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2014.
All research outputs
#18,374,472
of 22,758,248 outputs
Outputs from Tumor Biology
#1,370
of 2,622 outputs
Outputs of similar age
#163,468
of 227,594 outputs
Outputs of similar age from Tumor Biology
#62
of 105 outputs
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