| Title |
Brain cortical characteristics of lifetime cognitive ageing
|
|---|---|
| Published in |
Brain Structure and Function, September 2017
|
| DOI | 10.1007/s00429-017-1505-0 |
| Pubmed ID | |
| Authors |
Simon R. Cox, Mark E. Bastin, Stuart J. Ritchie, David Alexander Dickie, Dave C. Liewald, Susana Muñoz Maniega, Paul Redmond, Natalie A. Royle, Alison Pattie, Maria Valdés Hernández, Janie Corley, Benjamin S. Aribisala, Andrew M. McIntosh, Joanna M. Wardlaw, Ian J. Deary |
| Abstract |
Regional cortical brain volume is the product of surface area and thickness. These measures exhibit partially distinct trajectories of change across the brain's cortex in older age, but it is unclear which cortical characteristics at which loci are sensitive to cognitive ageing differences. We examine associations between change in intelligence from age 11 to 73 years and regional cortical volume, surface area, and thickness measured at age 73 years in 568 community-dwelling older adults, all born in 1936. A relative positive change in intelligence from 11 to 73 was associated with larger volume and surface area in selective frontal, temporal, parietal, and occipital regions (r < 0.180, FDR-corrected q < 0.05). There were no significant associations between cognitive ageing and a thinner cortex for any region. Interestingly, thickness and surface area were phenotypically independent across bilateral lateral temporal loci, whose surface area was significantly related to change in intelligence. These findings suggest that associations between regional cortical volume and cognitive ageing differences are predominantly driven by surface area rather than thickness among healthy older adults. Regional brain surface area has been relatively underexplored, and is a potentially informative biomarker for identifying determinants of cognitive ageing differences. |
X Demographics
The data shown below were collected from the profiles of 45 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 20% |
| Spain | 4 | 9% |
| United States | 4 | 9% |
| Netherlands | 3 | 7% |
| Italy | 1 | 2% |
| Australia | 1 | 2% |
| Mexico | 1 | 2% |
| Russia | 1 | 2% |
| Switzerland | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 18 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 60% |
| Scientists | 15 | 33% |
| Practitioners (doctors, other healthcare professionals) | 3 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 89 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 25% |
| Researcher | 19 | 21% |
| Student > Bachelor | 11 | 12% |
| Student > Doctoral Student | 5 | 6% |
| Professor | 3 | 3% |
| Other | 10 | 11% |
| Unknown | 19 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 22% |
| Psychology | 13 | 15% |
| Medicine and Dentistry | 6 | 7% |
| Mathematics | 4 | 4% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 31 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2019.
All research outputs
#1,177,943
of 25,196,456 outputs
Outputs from Brain Structure and Function
#61
of 1,753 outputs
Outputs of similar age
#23,489
of 321,289 outputs
Outputs of similar age from Brain Structure and Function
#3
of 38 outputs
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So far Altmetric has tracked 1,753 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 96% of its peers.
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