| Title |
Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction
|
|---|---|
| Published in |
European Spine Journal, July 2006
|
| DOI | 10.1007/s00586-006-0183-z |
| Pubmed ID | |
| Authors |
Victor Y. L. Leung, Danny Chan, Kenneth M. C. Cheung |
| Abstract |
Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect is suggested to be dependent on the severity of degeneration. Mesenchymal stem cells (MSCs) are able to escape alloantigen recognition which is an advantage for allogenic transplantation. A number of injectable scaffolds have been described and various methods to pre-modulate MSCs' activity have been tested. In future, work will need to address the use of mesenchymal stem cells in large animal models and the fate of the implanted mesenchymal stem cells, particularly in the long term, in animals. This review examines the state-of-the-art in the field of stem cell regeneration of the intervertebral disc, and critically discusses, with scientific support, the issues involved, before stem cells could be used in human subjects. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| France | 1 | <1% |
| India | 1 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 140 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 21% |
| Researcher | 18 | 12% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 12 | 8% |
| Other | 10 | 7% |
| Other | 39 | 26% |
| Unknown | 23 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 26% |
| Agricultural and Biological Sciences | 35 | 23% |
| Engineering | 29 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Veterinary Science and Veterinary Medicine | 4 | 3% |
| Other | 10 | 7% |
| Unknown | 26 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2017.
All research outputs
#6,966,178
of 24,274,366 outputs
Outputs from European Spine Journal
#830
of 4,993 outputs
Outputs of similar age
#21,469
of 68,121 outputs
Outputs of similar age from European Spine Journal
#8
of 22 outputs
Altmetric has tracked 24,274,366 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 4,993 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,121 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.