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Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies The Honolulu-Asia Aging Study

Overview of attention for article published in Diabetes, April 2002
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

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Title
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies The Honolulu-Asia Aging Study
Published in
Diabetes, April 2002
DOI 10.2337/diabetes.51.4.1256
Pubmed ID
Authors

Rita Peila, Beatriz L. Rodriguez, Lenore J. Launer

Abstract

Type 2 diabetes may be a risk factor for dementia, but the associated pathological mechanisms remains unclear. We evaluated the association of diabetes alone or combined with the apolipoprotein E (APOE) gene with incident dementia and neuropathological outcomes in a population-based cohort of 2,574 Japanese-American men enrolled in the Honolulu-Asia Aging Study, including 216 subjects who underwent autopsy. Type 2 diabetes was ascertained by interview and direct glucose testing. Dementia was assessed in 1991 and 1994 by clinical examination and magnetic resonance imaging and was diagnosed according to international guidelines. Logistic regression was used to assess the RR of developing dementia, and log-linear regression was used to estimate the incident rate ratio (IRR) of neuropathological outcomes. Diabetes was associated with total dementia (RR 1.5 [95% CI 1.01-2.2]), Alzheimer's disease (AD; 1.8 [1.1-2.9]), and vascular dementia (VsD; 2.3 [1.1-5.0]). Individuals with both type 2 diabetes and the APOE epsilon4 allele had an RR of 5.5 (CI 2.2-13.7) for AD compared with those with neither risk factor. Participants with type 2 diabetes and the epsilon4 allele had a higher number of hippocampal neuritic plaques (IRR 3.0 [CI 1.2-7.3]) and neurofibrillary tangles in the cortex (IRR 3.5 [1.6-7.5]) and hippocampus (IRR 2.5 [1.5-3.7]), and they had a higher risk of cerebral amyloid angiopathy (RR 6.6, 1.5-29.6). Type 2 diabetes is a risk factor for AD and VsD. The association between diabetes and AD is particularly strong among carriers of the APOE epsilon4 allele. The neuropathological data are consistent with the clinical results.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 519 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 1%
Bulgaria 2 <1%
India 2 <1%
United Kingdom 2 <1%
Australia 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 504 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 103 20%
Researcher 67 13%
Student > Bachelor 63 12%
Student > Master 49 9%
Professor > Associate Professor 25 5%
Other 92 18%
Unknown 120 23%
Readers by discipline Count As %
Medicine and Dentistry 109 21%
Agricultural and Biological Sciences 81 16%
Neuroscience 58 11%
Biochemistry, Genetics and Molecular Biology 50 10%
Psychology 25 5%
Other 63 12%
Unknown 133 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2020.
All research outputs
#1,031,118
of 23,368,819 outputs
Outputs from Diabetes
#397
of 9,325 outputs
Outputs of similar age
#881
of 122,873 outputs
Outputs of similar age from Diabetes
#4
of 81 outputs
Altmetric has tracked 23,368,819 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,325 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,873 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.