| Title |
Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control
|
|---|---|
| Published in |
Protein & Cell, July 2014
|
| DOI | 10.1007/s13238-014-0083-7 |
| Pubmed ID | |
| Authors |
Caiguo Zhang |
| Abstract |
Eukaryotic cells contain numerous iron-requiring proteins such as iron-sulfur (Fe-S) cluster proteins, hemoproteins and ribonucleotide reductases (RNRs). These proteins utilize iron as a cofactor and perform key roles in DNA replication, DNA repair, metabolic catalysis, iron regulation and cell cycle progression. Disruption of iron homeostasis always impairs the functions of these iron-requiring proteins and is genetically associated with diseases characterized by DNA repair defects in mammals. Organisms have evolved multi-layered mechanisms to regulate iron balance to ensure genome stability and cell development. This review briefly provides current perspectives on iron homeostasis in yeast and mammals, and mainly summarizes the most recent understandings on iron-requiring protein functions involved in DNA stability maintenance and cell cycle control. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 293 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 289 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 19% |
| Student > Bachelor | 40 | 14% |
| Student > Master | 38 | 13% |
| Researcher | 23 | 8% |
| Student > Doctoral Student | 17 | 6% |
| Other | 42 | 14% |
| Unknown | 77 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 72 | 25% |
| Agricultural and Biological Sciences | 50 | 17% |
| Medicine and Dentistry | 27 | 9% |
| Chemistry | 10 | 3% |
| Unspecified | 6 | 2% |
| Other | 34 | 12% |
| Unknown | 94 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2023.
All research outputs
#6,343,869
of 23,415,749 outputs
Outputs from Protein & Cell
#241
of 763 outputs
Outputs of similar age
#58,176
of 227,276 outputs
Outputs of similar age from Protein & Cell
#4
of 16 outputs
Altmetric has tracked 23,415,749 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 763 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,276 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.