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Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort

Overview of attention for article published in Development & Psychopathology, July 2014
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Title
Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort
Published in
Development & Psychopathology, July 2014
DOI 10.1017/s0954579414000649
Pubmed ID
Authors

Erica L. Smearman, D. Anne Winiarski, Patricia A. Brennan, Jake Najman, Katrina C. Johnson

Abstract

Polymorphisms in the oxytocin receptor gene are commonly associated with prosocial behaviors in the extant literature, yet their role in antisocial behaviors has rarely been explored, particularly during the transition from adolescence to early adulthood. We examined a prospective cohort (N = 404), collecting youth, mother, and clinician reports of conduct-disordered and antisocial behavior at ages 15 and 20. The oxytocin receptor gene rs53576 polymorphism was hypothesized to interact with social stress to predict antisocial outcomes. Structural equation modeling results revealed a significant main effect at age 15 (p = .025); those with the G allele exhibited higher levels of conduct problems. Structural equation modeling revealed a significant Gene × Environment interaction at age 20 (p = .029); those with the G allele who experienced high social stress exhibited higher levels of antisocial behavior. Heterozygous (AG) grouping models were compared, and parameter estimations supported G dominant groupings. These novel findings suggest that rs53576 polymorphisms may influence social salience and contribute to risk for antisocial outcomes, particularly under conditions of high social stress.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Unknown 98 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 20%
Student > Ph. D. Student 17 17%
Student > Bachelor 14 14%
Student > Master 12 12%
Student > Doctoral Student 9 9%
Other 14 14%
Unknown 13 13%
Readers by discipline Count As %
Psychology 39 39%
Neuroscience 12 12%
Agricultural and Biological Sciences 7 7%
Social Sciences 6 6%
Medicine and Dentistry 5 5%
Other 5 5%
Unknown 25 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2014.
All research outputs
#20,983,439
of 25,774,185 outputs
Outputs from Development & Psychopathology
#1,546
of 1,776 outputs
Outputs of similar age
#177,181
of 241,163 outputs
Outputs of similar age from Development & Psychopathology
#26
of 34 outputs
Altmetric has tracked 25,774,185 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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