| Title |
Effects of divergent resistance exercise contraction mode and dietary supplementation type on anabolic signalling, muscle protein synthesis and muscle hypertrophy
|
|---|---|
| Published in |
Amino Acids, July 2014
|
| DOI | 10.1007/s00726-014-1792-1 |
| Pubmed ID | |
| Authors |
Stine Klejs Rahbek, Jean Farup, Andreas Buch Møller, Mikkel Holm Vendelbo, Lars Holm, Niels Jessen, Kristian Vissing |
| Abstract |
Greater force produced with eccentric (ECC) compared to concentric (CONC) contractions, may comprise a stronger driver of muscle growth, which may be further augmented by protein supplementation. We investigated the effect of differentiated contraction mode with either whey protein hydrolysate and carbohydrate (WPH + CHO) or isocaloric carbohydrate (CHO) supplementation on regulation of anabolic signalling, muscle protein synthesis (MPS) and muscle hypertrophy. Twenty-four human participants performed unilateral isolated maximal ECC versus CONC contractions during exercise habituation, single-bout exercise and 12 weeks of training combined with WPH + CHO or CHO supplements. In the exercise-habituated state, p-mTOR, p-p70S6K, p-rpS6 increased by approximately 42, 206 and 213 %, respectively, at 1 h post-exercise, with resistance exercise per se; whereas, the phosphorylation was exclusively maintained with ECC at 3 and 5 h post-exercise. This acute anabolic signalling response did not differ between the isocaloric supplement types, neither did protein fractional synthesis rate differ between interventions. Twelve weeks of ECC as well as CONC resistance training augmented hypertrophy with WPH + CHO group compared to the CHO group (7.3 ± 1.0 versus 3.4 ± 0.8 %), independently of exercise contraction type. Training did not produce major changes in basal levels of Akt-mTOR pathway components. In conclusion, maximal ECC contraction mode may constitute a superior driver of acute anabolic signalling that may not be mirrored in the muscle protein synthesis rate. Furthermore, with prolonged high-volume resistance training, contraction mode seems less influential on the magnitude of muscle hypertrophy, whereas protein and carbohydrate supplementation augments muscle hypertrophy as compared to isocaloric carbohydrate supplementation . |
X Demographics
The data shown below were collected from the profiles of 55 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 15 | 27% |
| United States | 4 | 7% |
| Canada | 3 | 5% |
| Japan | 2 | 4% |
| Sweden | 1 | 2% |
| Finland | 1 | 2% |
| Saudi Arabia | 1 | 2% |
| Croatia | 1 | 2% |
| Spain | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 25 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 37 | 67% |
| Scientists | 14 | 25% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 132 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 16% |
| Student > Bachelor | 20 | 15% |
| Student > Ph. D. Student | 19 | 14% |
| Researcher | 12 | 9% |
| Student > Postgraduate | 10 | 7% |
| Other | 32 | 24% |
| Unknown | 20 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 20% |
| Sports and Recreations | 26 | 19% |
| Agricultural and Biological Sciences | 17 | 13% |
| Nursing and Health Professions | 15 | 11% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Other | 10 | 7% |
| Unknown | 30 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 54. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2023.
All research outputs
#750,396
of 24,567,524 outputs
Outputs from Amino Acids
#33
of 1,587 outputs
Outputs of similar age
#7,195
of 230,894 outputs
Outputs of similar age from Amino Acids
#4
of 24 outputs
Altmetric has tracked 24,567,524 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,587 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 97% of its peers.
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