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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sequencing-based approach identified three new susceptibility loci for psoriasis
|
|---|---|
| Published in |
Nature Communications, July 2014
|
| DOI | 10.1038/ncomms5331 |
| Pubmed ID | |
| Authors |
Yujun Sheng, Xin Jin, Jinhua Xu, Jinping Gao, Xiaoqing Du, Dawei Duan, Bing Li, Jinhua Zhao, Wenying Zhan, Huayang Tang, Xianfa Tang, Yang Li, Hui Cheng, Xianbo Zuo, Junpu Mei, Fusheng Zhou, Bo Liang, Gang Chen, Changbing Shen, Hongzhou Cui, Xiaoguang Zhang, Change Zhang, Wenjun Wang, Xiaodong Zheng, Xing Fan, Zaixing Wang, Fengli Xiao, Yong Cui, Yingrui Li, Jun Wang, Sen Yang, Lei Xu, Liangdan Sun, Xuejun Zhang |
| Abstract |
In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 10(-6). The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 25% |
| Researcher | 15 | 24% |
| Student > Master | 4 | 6% |
| Professor | 3 | 5% |
| Student > Doctoral Student | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 16 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 22% |
| Biochemistry, Genetics and Molecular Biology | 9 | 14% |
| Medicine and Dentistry | 7 | 11% |
| Immunology and Microbiology | 7 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Other | 4 | 6% |
| Unknown | 18 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#13,916,722
of 22,758,248 outputs
Outputs from Nature Communications
#39,605
of 46,869 outputs
Outputs of similar age
#114,428
of 225,950 outputs
Outputs of similar age from Nature Communications
#530
of 688 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 46,869 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,950 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 688 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.