| Title |
Subchronic toxicity of herbal compound “Jiedu Huayu” granules in rats
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, September 2017
|
| DOI | 10.1186/s12906-017-1960-4 |
| Pubmed ID | |
| Authors |
Minggang Wang, Hua Qiu, Rongzhen Zhang, Fuli Long, Dewen Mao |
| Abstract |
"Jiedu Huayu" (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is to evaluate the safety of JDHY granules. Subchronic toxicity was tested in male and female rats that were orally administered three different doses (80, 100, and 130 g/kg/d) of JDHY for 13 weeks. Clinical signs, bodyweight, food consumption, hematological and biochemical parameters, organ coefficients, and histological changes were observed during the study. There were no significant changes in toxicity observed in either sex at any dose of JDHY granules treatment. These results suggest that repeated oral administration of JDHY granules at dosage levels of ≤130 g/kg/d can be considered safe. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 17% |
| Student > Bachelor | 1 | 17% |
| Student > Doctoral Student | 1 | 17% |
| Student > Master | 1 | 17% |
| Unknown | 2 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 50% |
| Agricultural and Biological Sciences | 1 | 17% |
| Unknown | 2 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2017.
All research outputs
#20,446,373
of 23,001,641 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,988
of 3,641 outputs
Outputs of similar age
#275,643
of 315,600 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#75
of 99 outputs
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