| Title |
Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection
|
|---|---|
| Published in |
Virologica Sinica, September 2017
|
| DOI | 10.1007/s12250-017-4057-9 |
| Pubmed ID | |
| Authors |
Gary Wong, Shihua He, Vinayakumar Siragam, Yuhai Bi, Majambu Mbikay, Michel Chretien, Xiangguo Qiu |
| Abstract |
Q3G is a natural derivative of quercetin and is already widely used in various foods and drinks. Our results clearly demonstrated that Q3G exerts antiviral activity against ZIKV in both tissue culture and knockout mice, and that post-exposure in vivo treatment with Q3G could have a beneficial effect. In the future, Q3G should be tested in human cell lines (such as Huh-7, HeLa, or K048, a fetal brain neural stem cell line) to provide further data supporting its potential efficacy in humans; in addition, live viral loads or viremia should be tested in treated animals to supplement the survival results observed in this study. Although the treatment regimens will need to be further optimized (i.e., dosage, frequency of treatment, and administration routes), our results support the results of Q3G efficacy studies in nonhuman primates against ZIKV infection. Further studies will also be needed to investigate the mechanism of Q3G antiviral action, in order to obtain valuable insights into the design of novel targets for antiviral therapeutics in the future. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 118 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 20% |
| Student > Bachelor | 13 | 11% |
| Researcher | 11 | 9% |
| Student > Ph. D. Student | 11 | 9% |
| Student > Doctoral Student | 8 | 7% |
| Other | 14 | 12% |
| Unknown | 37 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 13% |
| Medicine and Dentistry | 12 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 9% |
| Agricultural and Biological Sciences | 8 | 7% |
| Immunology and Microbiology | 7 | 6% |
| Other | 20 | 17% |
| Unknown | 45 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2023.
All research outputs
#1,446,207
of 25,611,630 outputs
Outputs from Virologica Sinica
#28
of 673 outputs
Outputs of similar age
#28,175
of 324,002 outputs
Outputs of similar age from Virologica Sinica
#2
of 8 outputs
Altmetric has tracked 25,611,630 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 673 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.