| Title |
BRCA1 gene: function and deficiency
|
|---|---|
| Published in |
International Journal of Clinical Oncology, September 2017
|
| DOI | 10.1007/s10147-017-1182-2 |
| Pubmed ID | |
| Authors |
Miho Takaoka, Yoshio Miki |
| Abstract |
The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1. We introduce the mechanism and the latest report on homologous recombination repair, replication, involvement in checkpoint regulation, transcription, chromatin remodeling, and cytoplasmic function (centrosome regulation, apoptosis, selective autophagy), and consider the possibility of carcinogenesis from inhibition of the intracellular functions in each. We also consider the possibility of drug development based on each function. Finally, we will explain, from data obtained through basic research, that an appropriate regimen is important for raising the response rate for poly (ADP)-ribose polymerase inhibitors, in the case of low susceptibility, iatrogenic toxicity, tolerance, etc. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 239 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 45 | 19% |
| Student > Ph. D. Student | 30 | 13% |
| Student > Master | 24 | 10% |
| Researcher | 18 | 8% |
| Student > Postgraduate | 11 | 5% |
| Other | 31 | 13% |
| Unknown | 80 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 84 | 35% |
| Medicine and Dentistry | 27 | 11% |
| Agricultural and Biological Sciences | 22 | 9% |
| Immunology and Microbiology | 3 | 1% |
| Unspecified | 3 | 1% |
| Other | 14 | 6% |
| Unknown | 86 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2018.
All research outputs
#7,292,465
of 23,001,641 outputs
Outputs from International Journal of Clinical Oncology
#140
of 921 outputs
Outputs of similar age
#115,611
of 315,656 outputs
Outputs of similar age from International Journal of Clinical Oncology
#4
of 12 outputs
Altmetric has tracked 23,001,641 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 921 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,656 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.