| Title |
Chronic Contamination of Rats with 137Cesium Radionuclide: Impact on the Cardiovascular System
|
|---|---|
| Published in |
Cardiovascular Toxicology, March 2008
|
| DOI | 10.1007/s12012-008-9013-3 |
| Pubmed ID | |
| Authors |
Yann Guéguen, Philippe Lestaevel, Line Grandcolas, Cédric Baudelin, Stéphane Grison, Jean-René Jourdain, Patrick Gourmelon, Maâmar Souidi |
| Abstract |
Cardiovascular system impairment has been observed in children and in liquidators exposed to the Chernobyl nuclear power plant accident. No experimental studies of animals have analyzed whether these disorders might be attributed to chronic ingestion of low levels of cesium 137 ((137)Cs). Biochemical, physiological, and molecular markers of the cardiovascular system were analyzed in rats exposed through drinking water to (137)Cs at a dose of 500 Bq kg(-1) (6500 Bq l(-1)). Plasma concentrations of CK and CK-MB were higher (+52%, P < 0.05) in contaminated rats. No histological alteration of the heart was observed, but gene expression was modified in the atria. Specifically, levels of ACE (angiotensin converting enzyme) and BNP (brain natriuretic peptide) gene expression increased significantly (P < 0.05). ECG analysis did not disclose any arrhythmia except ST- and RT-segment shortening (-9% and -11%, respectively, P < 0.05) in rats exposed to (137)Cs. Mean blood pressure decreased (-10%, P < 0.05), and its circadian rhythm disappeared. Overall, chronic contamination by an extreme environmental dose of (137)Cs for 3 months did not result in cardiac morphological changes, but the cardiovascular system impairments we observed could develop into more significant changes in sensitive animals or after longer contamination. |
X Demographics
The data shown below were collected from the profiles of 141 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 62 | 44% |
| Germany | 2 | 1% |
| United States | 2 | 1% |
| Mali | 1 | <1% |
| Thailand | 1 | <1% |
| Unknown | 73 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 138 | 98% |
| Unknown | 3 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 19% |
| Student > Bachelor | 4 | 13% |
| Lecturer | 2 | 6% |
| Student > Postgraduate | 2 | 6% |
| Student > Master | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 11 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 19% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Agricultural and Biological Sciences | 2 | 6% |
| Environmental Science | 2 | 6% |
| Earth and Planetary Sciences | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 12 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 127. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2015.
All research outputs
#332,039
of 25,622,179 outputs
Outputs from Cardiovascular Toxicology
#6
of 323 outputs
Outputs of similar age
#578
of 95,340 outputs
Outputs of similar age from Cardiovascular Toxicology
#1
of 1 outputs
Altmetric has tracked 25,622,179 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 323 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them