| Title |
Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds
|
|---|---|
| Published in |
Malaria Journal, January 2014
|
| DOI | 10.1186/1475-2875-13-2 |
| Pubmed ID | |
| Authors |
Sean R Marcsisin, Jason C Sousa, Gregory A Reichard, Diana Caridha, Qiang Zeng, Norma Roncal, Ronan McNulty, Julio Careagabarja, Richard J Sciotti, Jason W Bennett, Victor E Zottig, Gregory Deye, Qigui Li, Lisa Read, Mark Hickman, N P Dhammika Nanayakkara, Larry A Walker, Bryan Smith, Victor Melendez, Brandon S Pybus |
| Abstract |
Tafenoquine (TQ) is an 8-aminoquinoline (8AQ) that has been tested in several Phase II and Phase III clinical studies and is currently in late stage development as an anti-malarial prophylactic agent. NPC-1161B is a promising 8AQ in late preclinical development. It has recently been reported that the 8AQ drug primaquine requires metabolic activation by CYP 2D6 for efficacy in humans and in mice, highlighting the importance of pharmacogenomics in the target population when administering primaquine. A logical follow-up study was to determine whether CYP 2D activation is required for other compounds in the 8AQ structural class. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 7 | 19% |
| United Kingdom | 5 | 14% |
| United States | 2 | 6% |
| New Zealand | 1 | 3% |
| Curaçao | 1 | 3% |
| Canada | 1 | 3% |
| France | 1 | 3% |
| Unknown | 18 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 31 | 86% |
| Scientists | 2 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| India | 1 | 1% |
| Unknown | 83 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 19% |
| Student > Ph. D. Student | 15 | 18% |
| Student > Master | 11 | 13% |
| Student > Bachelor | 9 | 11% |
| Other | 8 | 9% |
| Other | 11 | 13% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 29% |
| Medicine and Dentistry | 16 | 19% |
| Chemistry | 9 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Other | 6 | 7% |
| Unknown | 16 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2021.
All research outputs
#1,323,717
of 25,084,886 outputs
Outputs from Malaria Journal
#196
of 5,849 outputs
Outputs of similar age
#14,531
of 317,999 outputs
Outputs of similar age from Malaria Journal
#3
of 60 outputs
Altmetric has tracked 25,084,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,849 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,999 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.