Title |
Biology of Glioma Cancer Stem Cells
|
---|---|
Published in |
Molecules & Cells, July 2009
|
DOI | 10.1007/s10059-009-0111-2 |
Pubmed ID | |
Authors |
Deric M. Park, Jeremy N. Rich |
Abstract |
Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Switzerland | 2 | 1% |
Sweden | 1 | <1% |
France | 1 | <1% |
Russia | 1 | <1% |
Ukraine | 1 | <1% |
Unknown | 127 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 29% |
Researcher | 27 | 20% |
Professor > Associate Professor | 12 | 9% |
Student > Bachelor | 12 | 9% |
Student > Master | 9 | 7% |
Other | 23 | 17% |
Unknown | 14 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 37% |
Medicine and Dentistry | 24 | 18% |
Biochemistry, Genetics and Molecular Biology | 19 | 14% |
Neuroscience | 8 | 6% |
Computer Science | 3 | 2% |
Other | 13 | 10% |
Unknown | 19 | 14% |