| Title |
Vitamin D receptor gene FokI polymorphisms influence bone mass in adolescent football (soccer) players
|
|---|---|
| Published in |
European Journal of Applied Physiology, September 2009
|
| DOI | 10.1007/s00421-009-1191-6 |
| Pubmed ID | |
| Authors |
Maria Eduarda L. Diogenes, Flávia Fioruci Bezerra, Giselda M. K. Cabello, Pedro H. Cabello, Laura M. C. Mendonça, Astrogildo V. Oliveira Júnior, Carmen M. Donangelo |
| Abstract |
The genetic influence on bone mineralization during adolescence is unclear possibly due to modifying factors such as skeletal maturation and lifestyle. We evaluated the influence of polymorphisms of the vitamin D receptor (VDR) gene on longitudinal changes in bone mass, bone- and calcium-related hormones in 46 adolescent soccer players (11.8-14.2 years). Total body bone mineral content (TBMC) and density (TBMD) were measured at baseline and after 6 months. Insulin-like growth factor-I (IGF-1), testosterone, intact parathyroid hormone, and activity of plasma bone alkaline phosphatase were measured at baseline and after 3 months. The influence of FokI or TaqI VDR genotypes on changes in the outcome variables were analyzed by univariate ANOVA with adjustment for chronological age, skeletal age and body weight at baseline. At baseline, boys with Ff genotype had higher TBMC, TBMD, TBMD Z-score compared to those with FF genotype (P < 0.05). After 3 months, Ff boys also had higher increment in plasma IGF-1 (P < 0.05). FokI polymorphism did not influence changes in bone mass measurements after 6 months, although differences detected at baseline remained significant after 6 months. There were no differences in the outcome variables according to TaqI genotypes. This study demonstrates that FokI polymorphisms affect bone mass in Brazilian adolescent soccer players and suggests that the FokI effect on bone mineralization occurs during bone maturation, possibly at the initial pubertal stages. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 19% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Bachelor | 7 | 13% |
| Lecturer | 5 | 9% |
| Professor | 4 | 8% |
| Other | 12 | 23% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 30% |
| Sports and Recreations | 9 | 17% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Agricultural and Biological Sciences | 6 | 11% |
| Social Sciences | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 9 | 17% |
Attention Score in Context
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#17,285,668
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Outputs from European Journal of Applied Physiology
#3,318
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#84,137
of 99,181 outputs
Outputs of similar age from European Journal of Applied Physiology
#31
of 44 outputs
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