You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a
|
|---|---|
| Published in |
Nature Communications, July 2014
|
| DOI | 10.1038/ncomms5350 |
| Pubmed ID | |
| Authors |
Niraj S. Bende, Sławomir Dziemborowicz, Mehdi Mobli, Volker Herzig, John Gilchrist, Jordan Wagner, Graham M. Nicholson, Glenn F. King, Frank Bosmans |
| Abstract |
β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting commonly targeted S3b-S4 paddle motifs within BgNav1 voltage sensors into Kv2.1, we find that Dc1a interacts with the domain II voltage sensor. In contrast, Dc1a has little effect on sodium currents mediated by PaNav1 channels from the American cockroach even though their domain II paddle motifs are identical. When exploring regions responsible for PaNav1 resistance to Dc1a, we identified two residues within the BgNav1 domain II S1-S2 loop that when mutated to their PaNav1 counterparts drastically reduce toxin susceptibility. Overall, our results reveal a distinct region within insect Nav channels that helps determine Dc1a sensitivity, a concept that will be valuable for the design of insect-selective insecticides. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| United States | 1 | 20% |
| Japan | 1 | 20% |
| Canada | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Madagascar | 1 | 1% |
| Unknown | 75 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 22% |
| Researcher | 12 | 16% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Student > Bachelor | 5 | 6% |
| Other | 14 | 18% |
| Unknown | 14 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 32% |
| Biochemistry, Genetics and Molecular Biology | 13 | 17% |
| Chemistry | 9 | 12% |
| Neuroscience | 4 | 5% |
| Business, Management and Accounting | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 17 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 105. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2023.
All research outputs
#373,817
of 24,213,557 outputs
Outputs from Nature Communications
#6,041
of 51,490 outputs
Outputs of similar age
#3,323
of 230,876 outputs
Outputs of similar age from Nature Communications
#48
of 688 outputs
Altmetric has tracked 24,213,557 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,490 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,876 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 688 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.