Title |
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis
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Published in |
Molecular and Cellular Biochemistry, September 2017
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DOI | 10.1007/s11010-017-3188-5 |
Pubmed ID | |
Authors |
Fei Zhou, Xuejun Jiang, Lin Teng, Jun Yang, Jiawang Ding, Chao He |
Abstract |
In this study, we investigated the roles of RIP1/RIP3 mediated cardiomyocyte necroptosis in CVB3-induced acute myocarditis. Serum concentrations of creatinine kinase (CK), CK-MB, and cardiac troponin I were detected using a Hitachi Automatic Biochemical Analyzer in a mouse model of acute VMC. Histological changes in cardiac tissue were observed by light microscope and expression levels of RIP1/RIP3 in the cardiac tissue were detected via Western blot and immunohistochemistry. The data showed that RIP1/RIP3 was highly expressed in cardiomyocytes in the acute VMC mouse model and that the necroptosis pathway specific blocker, Nec-1, dramatically reduced the myocardial damage by downregulating the expression of RIP1/RIP3. These findings provide evidence that necroptosis plays a significant role in cardiomyocyte death and it is a major pathway for cell death in acute VMC. Blocking the necroptosis pathway may serve as a new therapeutic option for the treatment of acute viral myocarditis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Nigeria | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 21% |
Researcher | 3 | 16% |
Student > Master | 3 | 16% |
Student > Bachelor | 2 | 11% |
Student > Doctoral Student | 2 | 11% |
Other | 2 | 11% |
Unknown | 3 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 26% |
Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Engineering | 2 | 11% |
Immunology and Microbiology | 2 | 11% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 2 | 11% |
Unknown | 3 | 16% |