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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons
|
|---|---|
| Published in |
Nature Neuroscience, July 2014
|
| DOI | 10.1038/nn.3761 |
| Pubmed ID | |
| Authors |
Eline Pecho-Vrieseling, Claus Rieker, Sascha Fuchs, Dorothee Bleckmann, Maria Soledad Esposito, Paolo Botta, Chris Goldstein, Mario Bernhard, Ivan Galimberti, Matthias Müller, Andreas Lüthi, Silvia Arber, Tewis Bouwmeester, Herman van der Putten, Francesco Paolo Di Giorgio |
| Abstract |
In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain slices of HD mouse model, an ex vivo corticostriatal slice model and the corticostriatal pathway in vivo. Transneuronal propagation of mHTT was blocked by two different botulinum neurotoxins, each known for specifically inactivating a single critical component of the synaptic vesicle fusion machinery. Moreover, healthy human neurons in HD mouse model brain slices displayed non-cell autonomous changes in morphological integrity that were more pronounced when these neurons bore mHTT aggregates. Altogether, our findings suggest that transneuronal propagation of mHTT might be an important and underestimated contributor to the pathophysiology of HD. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 27% |
| Canada | 1 | 9% |
| Mexico | 1 | 9% |
| United Kingdom | 1 | 9% |
| Sweden | 1 | 9% |
| France | 1 | 9% |
| Unknown | 3 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 55% |
| Science communicators (journalists, bloggers, editors) | 3 | 27% |
| Scientists | 1 | 9% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 335 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 1% |
| United Kingdom | 4 | 1% |
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| Austria | 1 | <1% |
| China | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 320 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 81 | 24% |
| Researcher | 65 | 19% |
| Student > Bachelor | 47 | 14% |
| Student > Master | 35 | 10% |
| Other | 19 | 6% |
| Other | 50 | 15% |
| Unknown | 38 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 105 | 31% |
| Neuroscience | 84 | 25% |
| Biochemistry, Genetics and Molecular Biology | 40 | 12% |
| Medicine and Dentistry | 32 | 10% |
| Immunology and Microbiology | 4 | 1% |
| Other | 23 | 7% |
| Unknown | 47 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2020.
All research outputs
#1,160,178
of 24,993,752 outputs
Outputs from Nature Neuroscience
#1,771
of 5,556 outputs
Outputs of similar age
#11,264
of 232,326 outputs
Outputs of similar age from Nature Neuroscience
#28
of 66 outputs
Altmetric has tracked 24,993,752 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,556 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,326 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.