Title |
Accuracy of imputation to whole-genome sequence data in Holstein Friesian cattle
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Published in |
Genetics Selection Evolution, July 2014
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DOI | 10.1186/1297-9686-46-41 |
Pubmed ID | |
Authors |
Rianne van Binsbergen, Marco CAM Bink, Mario PL Calus, Fred A van Eeuwijk, Ben J Hayes, Ina Hulsegge, Roel F Veerkamp |
Abstract |
The use of whole-genome sequence data can lead to higher accuracy in genome-wide association studies and genomic predictions. However, to benefit from whole-genome sequence data, a large dataset of sequenced individuals is needed. Imputation from SNP panels, such as the Illumina BovineSNP50 BeadChip and Illumina BovineHD BeadChip, to whole-genome sequence data is an attractive and less expensive approach to obtain whole-genome sequence genotypes for a large number of individuals than sequencing all individuals. Our objective was to investigate accuracy of imputation from lower density SNP panels to whole-genome sequence data in a typical dataset for cattle. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 3 | 50% |
United Kingdom | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 67% |
Scientists | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 1% |
United States | 2 | 1% |
Netherlands | 1 | <1% |
Colombia | 1 | <1% |
Belgium | 1 | <1% |
New Zealand | 1 | <1% |
Unknown | 137 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 21% |
Researcher | 28 | 19% |
Student > Master | 19 | 13% |
Student > Doctoral Student | 13 | 9% |
Other | 6 | 4% |
Other | 15 | 10% |
Unknown | 34 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 88 | 61% |
Biochemistry, Genetics and Molecular Biology | 9 | 6% |
Veterinary Science and Veterinary Medicine | 6 | 4% |
Engineering | 3 | 2% |
Environmental Science | 1 | <1% |
Other | 4 | 3% |
Unknown | 34 | 23% |