Title |
Performance of 68Ga-PSMA PET/CT for Prostate Cancer Management at Initial Staging and Time of Biochemical Recurrence
|
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Published in |
Current Urology Reports, September 2017
|
DOI | 10.1007/s11934-017-0736-1 |
Pubmed ID | |
Authors |
Jason Bailey, Morand Piert |
Abstract |
Recently introduced Gallium-68 labeled PSMA-ligands such as HBED-CC ((68)Ga-PSMA) have shown promise for unmet diagnostic needs in prostate cancer. (68)Ga-PSMA has demonstrated improved detection rates and specificity for prostate cancer compared to standard imaging approaches. In the setting of primary disease, (68)Ga-PSMA appears to preferentially identify treatment-relevant intermediate and high-risk prostate cancer. There is also a growing evidence that (68)Ga-PSMA positron emission tomography (PET) outperforms alternative conventional imaging methods including choline-based radiotracers for the localization of disease sites at biochemical recurrence, particularly at lower prostate-specific antigen (PSA) levels (< 1 ng/mL). However, the majority of published work lacks rigorous verification of imaging results. (68)Ga-PSMA offers significant promise for both, primary disease and biochemically recurrent prostate cancer. The evidence base to support (68)Ga-PSMA is however still underdeveloped, and more rigorous studies substantiating efficacy are needed. |
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Mendeley readers
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Other | 7 | 11% |
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Unknown | 19 | 31% |