| Title |
A pilot study of IL-1 inhibition by anakinra in acute gout
|
|---|---|
| Published in |
Arthritis Research & Therapy, March 2007
|
| DOI | 10.1186/ar2143 |
| Pubmed ID | |
| Authors |
Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp |
| Abstract |
Monosodium urate crystals stimulate monocytes and macrophages to release IL-1beta through the NALP3 component of the inflammasome. The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested that IL-1 inhibition might also be effective in relieving the inflammatory manifestations of acute gout. The effectiveness of IL-1 inhibition was first evaluated in a mouse model of monosodium urate crystal-induced inflammation. IL-1 inhibition prevented peritoneal neutrophil accumulation but TNF blockade had no effect. Based on these findings, we performed a pilot, open-labeled study (trial registration number ISRCTN10862635) in 10 patients with gout who could not tolerate or had failed standard antiinflammatory therapies. All patients received 100 mg anakinra daily for 3 days. All 10 patients with acute gout responded rapidly to anakinra. No adverse effects were observed. IL-1 blockade appears to be an effective therapy for acute gouty arthritis. The clinical findings need to be confirmed in a controlled study. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 237 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 1% |
| Australia | 2 | <1% |
| France | 1 | <1% |
| Colombia | 1 | <1% |
| China | 1 | <1% |
| Unknown | 229 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 39 | 16% |
| Student > Ph. D. Student | 32 | 14% |
| Student > Master | 27 | 11% |
| Student > Bachelor | 24 | 10% |
| Other | 20 | 8% |
| Other | 57 | 24% |
| Unknown | 38 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 75 | 32% |
| Agricultural and Biological Sciences | 45 | 19% |
| Biochemistry, Genetics and Molecular Biology | 22 | 9% |
| Immunology and Microbiology | 10 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 3% |
| Other | 27 | 11% |
| Unknown | 50 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#2,174,657
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#387
of 3,381 outputs
Outputs of similar age
#5,063
of 89,168 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 16 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,168 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.