Title |
Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial
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Published in |
Neuro-Oncology, July 2014
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DOI | 10.1093/neuonc/nou138 |
Pubmed ID | |
Authors |
B. Wiestler, D. Capper, V. Hovestadt, M. Sill, D. T. W. Jones, C. Hartmann, J. Felsberg, M. Platten, W. Feiden, K. Keyvani, S. M. Pfister, O. D. Wiestler, R. Meyermann, G. Reifenberger, T. Pietsch, A. von Deimling, M. Weller, W. Wick |
Abstract |
Molecular biomarkers including isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation, 1p/19q codeletion, and O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation may improve prognostication and guide treatment decisions for patients with World Health Organization (WHO) anaplastic gliomas. At present, each marker is individually tested by distinct assays. Illumina Infinium HumanMethylation450 BeadChip arrays (HM450) enable the determination of large-scale methylation profiles and genome-wide DNA copy number changes. Algorithms have been developed to detect the glioma CpG island methylator phenotype (G-CIMP) associated with IDH1/2 mutation, 1p/19q codeletion, and MGMT promoter methylation using a single assay. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 25% |
Student > Ph. D. Student | 10 | 17% |
Student > Master | 6 | 10% |
Student > Postgraduate | 5 | 8% |
Student > Doctoral Student | 4 | 7% |
Other | 9 | 15% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 41% |
Agricultural and Biological Sciences | 7 | 12% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Neuroscience | 4 | 7% |
Psychology | 2 | 3% |
Other | 3 | 5% |
Unknown | 15 | 25% |