Title |
HSPA5 is an essential host factor for Ebola virus infection
|
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Published in |
Antiviral Research, July 2014
|
DOI | 10.1016/j.antiviral.2014.07.004 |
Pubmed ID | |
Authors |
St Patrick Reid, Amy C Shurtleff, Julie A Costantino, Sarah R Tritsch, Cary Retterer, Kevin B Spurgers, Sina Bavari |
Abstract |
Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the HSPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association. Furthermore, in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model. These findings demonstrate that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 15% |
United Kingdom | 1 | 8% |
Pakistan | 1 | 8% |
Germany | 1 | 8% |
Unknown | 8 | 62% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 69% |
Scientists | 2 | 15% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Kazakhstan | 1 | 1% |
United Kingdom | 1 | 1% |
Canada | 1 | 1% |
Denmark | 1 | 1% |
United States | 1 | 1% |
Angola | 1 | 1% |
Unknown | 85 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 21% |
Researcher | 19 | 21% |
Student > Bachelor | 11 | 12% |
Student > Master | 7 | 8% |
Other | 7 | 8% |
Other | 21 | 23% |
Unknown | 7 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 30% |
Medicine and Dentistry | 11 | 12% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Chemistry | 8 | 9% |
Immunology and Microbiology | 6 | 7% |
Other | 18 | 20% |
Unknown | 13 | 14% |