| Chapter title |
Cathepsins B1 and B2 of Trichobilharzia SPP., Bird Schistosomes Causing Cercarial Dermatitis
|
|---|---|
| Chapter number | 9 |
| Book title |
Cysteine Proteases of Pathogenic Organisms
|
| Published in |
Advances in experimental medicine and biology, January 2011
|
| DOI | 10.1007/978-1-4419-8414-2_9 |
| Pubmed ID | |
| Book ISBNs |
978-1-4419-8413-5, 978-1-4419-8414-2
|
| Authors |
Martin Kašný, Libor Mikeš, Kateřina Dolečková, Vladimír Hampl, Jan Dvořák, Marian Novotný, Petr Horák, Kašný, Martin, Mikeš, Libor, Dolečková, Kateřina, Hampl, Vladimír, Dvořák, Jan, Novotný, Marian, Horák, Petr |
| Abstract |
Trichobilharzia regenti and T. szidati are schistosomes that infect birds. although T. regenti/T. szidati can only complete their life cycle in specific bird hosts (waterfowl), their larvae-cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts (e.g., mouse, man). Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host and include cysteine peptidases such as cathepsins B1 and B2. These enzymes are indispensable bio-catalysts in a number of basal biological processes and host-parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes (T. regenti, T. szidati) and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 15% |
| Professor > Associate Professor | 3 | 15% |
| Researcher | 3 | 15% |
| Student > Master | 2 | 10% |
| Student > Ph. D. Student | 2 | 10% |
| Other | 4 | 20% |
| Unknown | 3 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 40% |
| Biochemistry, Genetics and Molecular Biology | 3 | 15% |
| Medicine and Dentistry | 2 | 10% |
| Immunology and Microbiology | 2 | 10% |
| Arts and Humanities | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 4 | 20% |