Neurodegenerative Diseases

Table of Contents

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   Book Overview
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   Chapter 1 Intracellular Signalling in Glutamate Excitotoxicity
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   Chapter 2 Long-Term Expression of Proenkephalin and Prodynorphin in the Rat Brain after Systemic Administration of Kainic Acid — an in Situ Hybridization Study
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   Chapter 3 Modulation of Vesicular Glutamate Release during Anoxia
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   Chapter 4 A Model for the Expression of Different Glutamate Transporter Proteins from a Rat Astrocyte-Type Glutamate Transporter Gene
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   Chapter 5 Glutamate Transporters: Molecular Mechanisms of Functional Alteration and Role in the Development of Excitotoxic Neuronal Injury
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   Chapter 6 Neurodegenerative Disease and Oxidative Stress: Insights from an Animal Model of Parkinsonism
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   Chapter 7 A Progressive Ballooning of Myelinated, TH-Positive Axons is Produced by MPTP in the Dog
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   Chapter 8 HIV-1 Coat Protein GP120 Induces Neuronal Injury to Cultured Dopamine Cells
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    Chapter 9 Platelets as Peripheral Model of Glutamate-Related Excitotoxicity in Parkinson’s Disease
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    Chapter 10 Brainstem Motoneuron Cell Groups that die in Amyotrophic Lateral Sclerosis are Rich in the GLT-1 Glutamate Transporter
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    Chapter 11 Progressive Neurodegeneration in Rat Brain after Chronic 3-VO or 2-VO
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    Chapter 12 In Vivo Biology of APP and its Homologues
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    Chapter 13 Lymphocyte Amyloid Precursor Protein mRNA Isoforms in Normal Aging and Alzheimer’s Disease
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    Chapter 14 Differential Regulation of APP Secretion by Apolipoprotein E3 and E4
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    Chapter 15 Apolipoprotein E Uptake is Increased by Beta-Amyloid Peptides and Reduced by Blockade of the LDL Receptor
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    Chapter 16 The Non-Amyloid-β Component of Alzheimer’s Disease Plaque Amyloid: Comparative Analysis Suggests a Normal Function as a Synaptic Plasticizer
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    Chapter 17 Mutations of Human Cu, Zn Superoxide Dismutase Expressed in Transgenic Mice Cause Motor Neuron Disease
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    Chapter 18 Effect of the Kennedy Mutation of the Androgen Receptor on Gene Expression in Neuroblastoma Cells
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    Chapter 19 Glutamate-Promoted Survival in Hippocampal Neurons: A Defect in Mouse Trisomy 16
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    Chapter 20 RNA Message Levels in Normally Aging and in Alzheimer’s Disease(AD)-Affected Human Temporal Lobe Neocortex
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    Chapter 21 Functional Activation of Energy Metabolism in Nervous Tissue: Where and Why
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    Chapter 22 Bioenergetics in Oxidative Damage in Neurodegenerative Diseases
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    Chapter 23 Is there a Relationship between Conditions Associated with Chronic Hypoxia, the Mitochondria, and Neurodegenerative Diseases, Such as Alzheimer’s Disease?
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    Chapter 24 α-Ketoglutarate Dehydrogenase in Alzheimer’s Disease
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    Chapter 25 Thiamine Deficiency as a Model of Selective Neurodegeneration with Chronic Oxidative Deficits
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    Chapter 26 Metabolic Failure, Oxidative Stress, and Neurodegeneration Following Cerebral Ischemia and Reperfusion
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    Chapter 27 Global Brain Ischemia and Reperfusion: Translation Initiation Factors
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    Chapter 28 Batten Disease: A Typical Neuronal Storage Disease or a Genetic Neurodegenerative Disorder Characterized by Excitotoxicity?
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    Chapter 29 Endogenous Amino Acid Profile during in Vitro Differentiation of Neural Stem Cells
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    Chapter 30 The Protective Action of Nitrone-Based Free Radical Traps in Neurodegenerative Diseases
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    Chapter 31 Nitric Oxide Actions in the Nervous System
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    Chapter 32 An Inflammatory Role for Nitric Oxide during Experimental Meningitis in the Rat
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    Chapter 33 Oxidative Stress Plays a Role in the Pathogenesis of Familial and Sporadic Amyotrophic Lateral Sclerosis
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    Chapter 34 Modulation of the Mitochondrial Anti-Oxygen Radical Defense of Rat Astroglial Cells in Culture
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    Chapter 35 Oxygen Radical-Mediated Oxidation of Serotonin: Potential Relationship to Neurodegenerative Diseases
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    Chapter 36 Dopamine Covalently Modifies DNA in a Tyrosinase-Enhanced Manner
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    Chapter 37 Brain [52FE]-Transferrin Uptake in Patients with Alzheimer’s Disease and Healthy Subjects: A Positron Emission Tomography (PET) Study
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    Chapter 38 βAPP Metabolites, Radicals, Calcium, and Neurodegeneration: Novel Neuroprotective Strategies
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    Chapter 39 Channel Formation by a Neurotoxic Beta Amyloid Peptide, Aβ25–35
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    Chapter 40 Cysteine String Proteins: Presynaptic Function and Dysfunction
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    Chapter 41 AIDS Dementia as a Form of Excitotoxicity: Potential Therapy with NMDA Open-Channel Blockers and Redox Congeners of Nitric Oxide
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    Chapter 42 Calcium, AMPA/Kainate Receptors, and Selective Neurodegeneration
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    Chapter 43 Diltiazem and MK-801 but not APV Act Synergistically to Protect Rat Hippocampal Slices against Hypoxic Damage
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    Chapter 44 Intracellular Calcium Stores and Ischemic Neuronal Death
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    Chapter 45 Calpain, a Catabolic Mediator in Spinal Cord Trauma
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    Chapter 46 Detection of Single and Double Strand DNA Breaks during Excitotoxic or Apoptotic Neuronal Cell Death
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    Chapter 47 Signalling for Survival: Potential Applications of Signal-Transduction Therapies for Suppression of Apoptosis in the Nervous System
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    Chapter 48 Ciliary Neurotrophic Factor (CNTF): Possible Implications in the Pathogenesis of Amyotrophic Lateral Sclerosis
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    Chapter 49 Neuronal Differentiation of PC12 Cells in the Absence of Extracellular Matrix Adhesion Induces Apoptosis
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    Chapter 50 Excitable Membrane-Derived Lipid Mediators: Glutamate Release and Regulation of Gene Expression
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    Chapter 51 Bcl-2 Protection of Mitochondrial Function Following Chemical Hypoxia/Aglycemia
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    Chapter 52 Biochemical Characteristics of Oxygen-Induced and Low K + Medium-Induced Apoptotic Neuronal Death
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    Chapter 53 Mechanisms of Selective Neuronal Vulnerability to 1-Methyl-4-Phenylpyridinium (MPP+) Toxicity
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    Chapter 54 Potential Role of Hyperactivation of Signal Transduction Pathways in Alzheimer’s Disease: Protein Kinase C Regulates PHF-like Phosphorylation of Tau within Neuronal Cells