| Title |
Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
|
|---|---|
| Published in |
Diabetologia, April 2010
|
| DOI | 10.1007/s00125-010-1760-6 |
| Pubmed ID | |
| Authors |
L. Sciacca, M. F. Cassarino, M. Genua, G. Pandini, R. Le Moli, S. Squatrito, R. Vigneri |
| Abstract |
Five insulin analogues, with modified insulin-like molecular structures, are currently approved for treating diabetic patients. They activate cell signalling and biological responses via insulin receptor isoforms (IR-A and IR-B), each having specific characteristics for eliciting cell responses. The molecular and biological effects of these analogues on receptor isoforms in comparison to native insulin are not well defined, and their effects on the IGF1 receptor (IGF1R) are controversial. The characterisation of these effects was the aim of the present study. |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 2 | 2% |
| Italy | 1 | 1% |
| Chile | 1 | 1% |
| United Kingdom | 1 | 1% |
| Japan | 1 | 1% |
| Unknown | 91 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 21% |
| Student > Ph. D. Student | 16 | 16% |
| Student > Master | 10 | 10% |
| Student > Bachelor | 8 | 8% |
| Student > Doctoral Student | 5 | 5% |
| Other | 11 | 11% |
| Unknown | 27 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 23% |
| Agricultural and Biological Sciences | 21 | 22% |
| Biochemistry, Genetics and Molecular Biology | 14 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Nursing and Health Professions | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 26 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2024.
All research outputs
#2,470,437
of 25,339,932 outputs
Outputs from Diabetologia
#1,260
of 5,337 outputs
Outputs of similar age
#8,834
of 102,595 outputs
Outputs of similar age from Diabetologia
#3
of 39 outputs
Altmetric has tracked 25,339,932 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,337 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,595 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.