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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
|
|---|---|
| Published in |
Science, July 2014
|
| DOI | 10.1126/science.1256942 |
| Pubmed ID | |
| Authors |
Lisa C Osborne, Laurel A Monticelli, Timothy J Nice, Tara E Sutherland, Mark C Siracusa, Matthew R Hepworth, Vesselin T Tomov, Dmytro Kobuley, Sara V Tran, Kyle Bittinger, Aubrey G Bailey, Alice L Laughlin, Jean-Luc Boucher, E John Wherry, Frederic D Bushman, Judith E Allen, Herbert W Virgin, David Artis |
| Abstract |
The mammalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathogens, including helminth parasites. Helminths induce potent immunomodulatory effects, but whether these effects are mediated by direct regulation of host immunity or indirectly through eliciting changes in the microbiota is unknown. We tested this in the context of virus-helminth coinfection. Helminth coinfection resulted in impaired antiviral immunity and was associated with changes in the microbiota and STAT6-dependent helminth-induced alternative activation of macrophages. Notably, helminth-induced impairment of antiviral immunity was evident in germ-free mice, but neutralization of Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, could partially restore antiviral immunity. These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1. |
X Demographics
The data shown below were collected from the profiles of 53 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 30% |
| United Kingdom | 4 | 8% |
| Finland | 2 | 4% |
| Australia | 2 | 4% |
| Spain | 1 | 2% |
| Switzerland | 1 | 2% |
| Singapore | 1 | 2% |
| Turkey | 1 | 2% |
| Ecuador | 1 | 2% |
| Other | 6 | 11% |
| Unknown | 18 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 34 | 64% |
| Scientists | 15 | 28% |
| Practitioners (doctors, other healthcare professionals) | 4 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 361 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 2% |
| United Kingdom | 4 | 1% |
| Korea, Republic of | 2 | <1% |
| Sweden | 1 | <1% |
| Finland | 1 | <1% |
| Denmark | 1 | <1% |
| Brazil | 1 | <1% |
| Thailand | 1 | <1% |
| Netherlands | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 342 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 101 | 28% |
| Researcher | 83 | 23% |
| Student > Master | 28 | 8% |
| Student > Bachelor | 25 | 7% |
| Student > Doctoral Student | 24 | 7% |
| Other | 63 | 17% |
| Unknown | 37 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 119 | 33% |
| Immunology and Microbiology | 89 | 25% |
| Medicine and Dentistry | 42 | 12% |
| Biochemistry, Genetics and Molecular Biology | 32 | 9% |
| Veterinary Science and Veterinary Medicine | 8 | 2% |
| Other | 28 | 8% |
| Unknown | 43 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#730,130
of 26,017,215 outputs
Outputs from Science
#15,449
of 83,593 outputs
Outputs of similar age
#6,479
of 231,107 outputs
Outputs of similar age from Science
#199
of 912 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,593 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,107 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 912 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.